Funding agencies: This work was supported by grants from the Bosch Foundation (to S.A.S.), the German Research Foundation (DFG; to M.K.), the Bachmann-Strauss Dystonia Parkinson Foundation (to J.H.), the Volkswagen Foundation (Lichtenberg Grant; to C.K.), and the Hermann and Lilly Schilling Foundation (to C.K.).
Article first published online: 2 OCT 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 12, pages 1563–1566, October 2012
How to Cite
Schneider, S. A., Drude, L., Kasten, M., Klein, C. and Hagenah, J. (2012), A study of subtle motor signs in early Parkinson's disease. Mov. Disord., 27: 1563–1566. doi: 10.1002/mds.25161
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 18 OCT 2012
- Article first published online: 2 OCT 2012
- Manuscript Accepted: 27 JUL 2012
- Manuscript Revised: 18 JUL 2012
- Manuscript Received: 9 MAY 2012
- Parkinons's disease;
- early phase;
- subtle motor signs;
- rating scale;
- earliest features
The UPDRS is the most widely used rating scale for Parkinson's disease (PD). However, subtle features of early disease stages may be missed.
We studied 25 early PD patients using a newly compiled battery of motor tests focusing on subtle motor features. Focal dystonia patients (n = 31) and healthy individuals (n = 26) served as controls. Specifically, asymmetric shoulder null position and delayed shoulder shrugs, reduced arm swing, subtle tremor, and timed finger taps were assessed. Spiral drawings and writing were also studied.
With a total mean of 9.8 ± 4.9 (possible range: 0–94), PD patients scored significantly higher than dystonia patients (2.9 ± 2.0) and healthy controls (1.9 ± 2.0) (P < 0.001). Reduced arm swing and tremor of individual fingers best distinguished PD from the other groups.
The battery was sensitive to detect subtle motor features missed by the UPDRS. For future revisions of an international motor score, further assessment of these items may be worthwhile. © 2012 Movement Disorder Society