Funding agencies: This work was supported by Ministerio de Ciencia e Innovación, Spain (PSI2008-03175).
Article first published online: 2 OCT 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 12, pages 1570–1573, October 2012
How to Cite
Fernández-Del-Olmo, M., Bello, O., Lopez-Alonso, V., Andrés Sanchez, J., Santos-García, D. and Valls-Solé, J. (2012), The effects of auditory startle and nonstartle stimuli on step initiation in Parkinson's disease. Mov. Disord., 27: 1570–1573. doi: 10.1002/mds.25168
Relevant conflicts of interest/financial
disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 18 OCT 2012
- Article first published online: 2 OCT 2012
- Manuscript Accepted: 30 JUL 2012
- Manuscript Revised: 13 JUL 2012
- Manuscript Received: 13 JAN 2012
- gait initation;
- step initiation;
Auditory external cues enhance step initiation in Parkinson's disease (PD) patients. We wanted to explore whether a startle reaction has a comparable effect on step initiation in PD.
Thirteen PD patients and 13 aged-matched controls participated in this study. Electromyography pattern and onset toe-off time during a step initiation task were recorded in response to three different stimuli: a visual imperative stimulus; visual stimulus simultaneous with a nonstartle auditory stimulus and with a startle auditory stimulus.
In all subjects, onset of tibialis anterior was faster in the startle auditory condition, compared with the nonstartle auditory condition. However, in the patient group, there was no difference in onset of soleus and toe-off between the startle and nonstartle conditions.
Startle reaction in PD patients demonstrates a disordered coupling between the anticipatory postural adjustments that initiate the weight shift and the movement to initiate toe-off during step initiation. © 2012 Movement Disorder Society