Funding agencies: This work was supported by the French Health Ministry (annual allowance to the French Reference Center for MSA).
Article first published online: 2 OCT 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 12, pages 1574–1577, October 2012
How to Cite
Meissner, W. G., Foubert-Samier, A., Dupouy, S., Gerdelat-Mas, A., Debs, R., Marquant, F., De Cock, V. C., Rascol, O., Tison, F. and Pavy-Le Traon, A. (2012), Assessment of quality of life with the multiple system atrophy health-related quality of life scale. Mov. Disord., 27: 1574–1577. doi: 10.1002/mds.25174
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 18 OCT 2012
- Article first published online: 2 OCT 2012
- Manuscript Accepted: 5 AUG 2012
- Manuscript Revised: 30 JUN 2012
- Manuscript Received: 8 MAY 2012
- atypical parkinsonism;
- sample-size estimate
Multiple system atrophy (MSA) has considerable effect on health-related quality of life (Hr-QoL). The aim of this study was to prospectively evaluate Hr-QoL by using the MSA health-related Quality of Life (MSA-QoL) scale.
Evaluation of 100 patients at baseline and after a mean follow-up of 11.5 months was performed. Assessment was made of potential associations with established markers of disease progression. Calculation was performed of sample-size estimates for various effect sizes.
MSA-QoL scale scores were less responsive to change than Unified MSA Rating Scale (UMSARS) scores. Responsiveness was largely improved and reasonable sample-size estimates were obtained when limiting the analysis to items with significant change over time.
The UMSARS remains the “gold standard” for disease-modifying/neuroprotection trials. An MSA-QoL Change Scale, based on the most responsive items, may become a valuable tool. © 2012 Movement Disorder Society