Get access

Assessment of quality of life with the multiple system atrophy health-related quality of life scale§

Authors

  • Wassilios G. Meissner MD, PhD,

    Corresponding author
    1. Centre de Référence Atrophie Multisystématisée, CHU de Bordeaux, Pessac, France
    2. Service de Neurologie, CHU de Bordeaux, Pessac, France
    3. Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    4. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    • Department of Neurology, University Hospital Bordeaux, Avenue Magellan, 33604 Pessac, France
    Search for more papers by this author
  • Alexandra Foubert-Samier MD,

    1. Centre de Référence Atrophie Multisystématisée, CHU de Bordeaux, Pessac, France
    2. Service de Neurologie, CHU de Bordeaux, Pessac, France
    Search for more papers by this author
  • Sandrine Dupouy MS,

    1. Centre de Référence Atrophie Multisystématisée, CHU de Bordeaux, Pessac, France
    2. Service de Neurologie, CHU de Bordeaux, Pessac, France
    Search for more papers by this author
  • Angélique Gerdelat-Mas MD,

    1. Centre de Référence Atrophie Multisystématisée, CHU de Toulouse, Toulouse, France
    Search for more papers by this author
  • Rachel Debs MD,

    1. Centre de Référence Atrophie Multisystématisée, CHU de Toulouse, Toulouse, France
    Search for more papers by this author
  • Fabienne Marquant PhD,

    1. CHU de Bordeaux, Unité de Soutien Méthodologique à la Recherche Clinique (USMR), Bordeaux, France
    Search for more papers by this author
  • Valérie Cochen De Cock MD, PhD,

    1. Centre de Référence Atrophie Multisystématisée, CHU de Toulouse, Toulouse, France
    Search for more papers by this author
  • Olivier Rascol MD, PhD,

    1. Centre de Référence Atrophie Multisystématisée, CHU de Toulouse, Toulouse, France
    2. Départements de Pharmacologie Clinique et Neurosciences, INSERM CIC9302, CHU de Toulouse, Toulouse, France
    Search for more papers by this author
  • François Tison MD, PhD,

    1. Centre de Référence Atrophie Multisystématisée, CHU de Bordeaux, Pessac, France
    2. Service de Neurologie, CHU de Bordeaux, Pessac, France
    3. Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    4. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    Search for more papers by this author
  • Anne Pavy-Le Traon MD, PhD

    1. Centre de Référence Atrophie Multisystématisée, CHU de Toulouse, Toulouse, France
    Search for more papers by this author

  • Funding agencies: This work was supported by the French Health Ministry (annual allowance to the French Reference Center for MSA).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Background:

Multiple system atrophy (MSA) has considerable effect on health-related quality of life (Hr-QoL). The aim of this study was to prospectively evaluate Hr-QoL by using the MSA health-related Quality of Life (MSA-QoL) scale.

Methods:

Evaluation of 100 patients at baseline and after a mean follow-up of 11.5 months was performed. Assessment was made of potential associations with established markers of disease progression. Calculation was performed of sample-size estimates for various effect sizes.

Results:

MSA-QoL scale scores were less responsive to change than Unified MSA Rating Scale (UMSARS) scores. Responsiveness was largely improved and reasonable sample-size estimates were obtained when limiting the analysis to items with significant change over time.

Conclusions:

The UMSARS remains the “gold standard” for disease-modifying/neuroprotection trials. An MSA-QoL Change Scale, based on the most responsive items, may become a valuable tool. © 2012 Movement Disorder Society

Ancillary