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The Unified Multiple System Atrophy Rating Scale: Intrarater reliability

Authors

  • Florian Krismer MD,

    1. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
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    • Dr. Krismer and Dr. Seppi contributed equally to this article

  • Klaus Seppi MD,

    1. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
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    • Dr. Krismer and Dr. Seppi contributed equally to this article

  • François Tison MD, PhD,

    1. Department of Neurology and French Reference Center for MSA, University Hospital Bordeaux and Institute for Neurodegenerative Diseases, CNRS UMR 5293, University Bordeaux 2, Bordeaux, France
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  • Cristina Sampaio MD,

    1. Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa, Lisboa, Portugal
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  • Anja Zangerl MD,

    1. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
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  • Cecilia Peralta MD,

    1. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    2. Department of Neurology, CEMIC (Center for Medical Education and Clinical Research), Buenos Aires, Argentina
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  • Farid Yekhlef MD,

    1. Department of Neurology and French Reference Center for MSA, University Hospital Bordeaux and Institute for Neurodegenerative Diseases, CNRS UMR 5293, University Bordeaux 2, Bordeaux, France
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  • Imad Ghorayeb MD,

    1. Department of Neurology and French Reference Center for MSA, University Hospital Bordeaux and Institute for Neurodegenerative Diseases, CNRS UMR 5293, University Bordeaux 2, Bordeaux, France
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  • Fabienne Ory-Magne MD,

    1. Departments of Clinical Pharmacology and Neurosciences, CIC-9302/INSERM UMR825: French Reference Center for MSA, University Hospital and University Paul Sabatier Toulouse III, Toulouse, France
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  • Monique Galitzky MD,

    1. Departments of Clinical Pharmacology and Neurosciences, CIC-9302/INSERM UMR825: French Reference Center for MSA, University Hospital and University Paul Sabatier Toulouse III, Toulouse, France
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  • Maria Bozi MD,

    1. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
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  • Tommaso Scaravilli MD,

    1. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    2. U.O.C. Neurologia, Ospedale dell'Angelo, Venice, Italy
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  • Carlo Colosimo MD,

    1. Department of Neurology and Psychiatry, Sapienza University, Rome, Italy
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  • Felix Geser MD, PhD,

    1. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    2. Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
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  • Olivier Rascol MD,

    1. Departments of Clinical Pharmacology and Neurosciences, CIC-9302/INSERM UMR825: French Reference Center for MSA, University Hospital and University Paul Sabatier Toulouse III, Toulouse, France
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  • Werner Poewe MD,

    1. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
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  • Niall P. Quinn MD,

    1. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
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  • Gregor K. Wenning MD, PhD, MSc,

    Corresponding author
    1. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    • Division of Neurobiology, Department of Neurology and Neurosurgery, Innsbruck Medical University, Anichstraße 35, A-6020 Innsbruck, Austria
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  • on behalf of the European Multiple System Atrophy Study Group


  • Funding agencies: This study was supported by funds of the 5th framework program of the European Community (QLK6-CT-2000-00661) and the Austrian Science Fund (FWF; F04404-B19).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Background:

The Unified Multiple System Atrophy Rating Scale (UMSARS) was developed to provide a surrogate measure of disease progression in multiple system atrophy. In the present study, the intrarater agreement of the motor examination part of the UMSARS was determined.

Methods:

All patients were first examined face to face, while being video-recorded, by two senior and two junior investigators. The patients' videotaped examinations were reevaluated after 3 months. Intrarater reliability for each item was analyzed by kappa statistics.

Results:

Overall weighted kappa (κ) values were at least substantial or excellent for all UMSARS motor examination items, except for ocular motor dysfunction, which showed only moderate intrarater agreement. Intrarater reliability was comparable between senior and junior raters, with all κ differences being ≤ 0.22.

Conclusions:

The motor examination part of the UMSARS was found to have satisfactory intrarater reliability in the present cohort. © 2012 Movement Disorder Society

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