Dr. Behnke and Dr. Seppi contributed equally
Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease
Article first published online: 31 OCT 2012
Copyright © 2012 Movement Disorders Society
Volume 28, Issue 2, pages 216–219, February 2013
How to Cite
Berg, D., Behnke, S., Seppi, K., Godau, J., Lerche, S., Mahlknecht, P., Liepelt-Scarfone, I., Pausch, C., Schneider, N., Gaenslen, A., Brockmann, K., Srulijes, K., Huber, H., Wurster, I., Stockner, H., Kiechl, S., Willeit, J., Gasperi, A., Fassbender, K., Gasser, T. and Poewe, W. (2013), Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease. Mov. Disord., 28: 216–219. doi: 10.1002/mds.25192
Funding agencies: This work was supported by The Michael J. Fox Foundation. Additionally, P.M. has been sponsored by a research grant from the Medical University of Innsbruck (IFTZ 2007152).
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 23 FEB 2013
- Article first published online: 31 OCT 2012
- Manuscript Accepted: 20 AUG 2012
- Manuscript Revised: 18 JUL 2012
- Manuscript Received: 25 APR 2012
- substantia nigra hyperechogenicity;
- transcranial sonography;
- risk marker;
- Parkinson's disease;
- relative risk
SN hyperechogenicity (SN+), determined by transcranial sonography, has been proposed as a risk factor for Parkinson's disease (PD). Recently, we reported a 17.4-fold increased risk for PD in individuals with SN+ older than 50 years within 3 years.
This is the second follow-up of a prospective, longitudinal, three-center observational study after 5 years. Of the initial 1,847 at baseline PD-free participants 50 years or older, 1,271 underwent the 5-year reassessment.
Within 5 years, 21 individuals developed incident PD. Participants with SN+ at baseline had a more than 20.6 times increased risk to develop PD in this time span than those without this echo feature.
We thus confirm our finding of the 3-year follow-up examination in a longer observation time and higher number of individuals with incident PD and suggest SN+ as an important risk marker for PD. © 2012 Movement Disorder Society