Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 31 OCT 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 14, pages 1729–1737, December 2012
How to Cite
Peeraully, T., Yong, M.-H., Chokroverty, S. and Tan, E.-K. (2012), Sleep and Parkinson's disease: A review of case-control polysomnography studies. Mov. Disord., 27: 1729–1737. doi: 10.1002/mds.25197
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 31 DEC 2012
- Article first published online: 31 OCT 2012
- Manuscript Accepted: 20 AUG 2012
- Manuscript Revised: 6 AUG 2012
- Manuscript Received: 9 MAY 2012
- obstructive sleep apnea;
- REM behavior disorder;
- periodic leg movements
The link between Parkinson's disease (PD) and certain primary sleep disorders has yet to be clarified. We performed a systematic review of case-control polysomnography studies to evaluate the relationship between PD and sleep disorders. A PubMed literature search and bibliography review yielded 15 case-control polysomnography studies in patients with PD. Studies differed by recruitment methods, duration of polysomnography monitoring, and sleep parameters measured. Subjective sleepiness was greater in patients than controls (50%–66% vs 2.9%–12%) despite lack of objective increase in daytime sleepiness by mean sleep latency testing. The 4 case-control polysomnography studies investigating rapid eye movement behavior disorder support a higher prevalence in PD (0%–47% vs 0%–1.8% in controls), although differences in diagnostic criteria hamper interpretation. The preponderance of evidence did not support an increased incidence of obstructive sleep apnea (27%–60% vs 13%–65%) or periodic leg movements of sleep in patients compared to controls. Adequately powered, prospective studies with uniform methodology and healthy controls are needed to further address the association and pathophysiological significance between PD and sleep problems. © 2012 Movement Disorder Society