Funding agencies: This work was supported by Abbott Healthcare B.V. (formerly Solvay Pharmaceuticals Laboratories).
Levodopa infusion does not decrease the onset of abnormal involuntary movements in parkinsonian rats
Version of Record online: 2 NOV 2012
Copyright © 2012 Movement Disorders Society
Volume 28, Issue 8, pages 1072–1079, July 2013
How to Cite
Papathanou, M., van der Laan, R., Jenner, P., Rose, S. and McCreary, A. C. (2013), Levodopa infusion does not decrease the onset of abnormal involuntary movements in parkinsonian rats. Mov. Disord., 28: 1072–1079. doi: 10.1002/mds.25218
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the Acknowledgments section online.
- Issue online: 12 AUG 2013
- Version of Record online: 2 NOV 2012
- Manuscript Accepted: 30 AUG 2012
- Manuscript Revised: 22 AUG 2012
- Manuscript Received: 17 APR 2012
- Parkinson's disease;
- intraduodenal levodopa infusion;
- 6-OHDA-lesioned rats;
The short duration of effect of levodopa is linked to pulsatile stimulation of striatal dopamine receptors and dyskinesia induction. However, the recent introduction of intraduodenal (i.d.) infusions and novel oral controlled release formulations of l-dopa may prevent dyskinesia induction and reduce the severity of established involuntary movements. We have compared the effects of twice-daily intraperitoneal (i.p.) administration and daily i.d. infusion of l-dopa on the induction and expression of abnormal involuntary movements in 6-hydroxydopamine (6-OHDA)-lesioned rats. Animals were treated with either twice-daily i.p. administration of l-dopa/carbidopa (7.85/12.5 mg/kg) or an 8-hour i.d. infusion of l-dopa/carbidopa (20/5 mg/mL; infusion rate: 0.04 mL/h) for 14 days, after which treatments were switched between groups and continued for a further 14 days. Pulsatile i.p. administration of l-dopa induced moderate to severe abnormal involuntary movements, which gradually increased in severity over the 14 days, but i.d. infusion of l-dopa induced abnormal involuntary movements of a similar severity. Switching from continuous i.d. to pulsatile i.p. administration of l-dopa continued to provoke severe abnormal involuntary movements expression. Switching from pulsatile i.p. to continuous i.d. l-dopa administration did not alter the peak abnormal involuntary movement severity but tended to reduce their duration. Treatment with less pulsatile l-dopa administration using i.d. infusion does not reduce the risk of the appearance of dyskinesia. By contrast, the duration of established dyskinesia can be reduced by more continuous l-dopa delivery in agreement with clinical experience. © 2012 Movement Disorder Society