Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 28 NOV 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 13, pages 1673–1678, November 2012
How to Cite
Frauscher, B., Ehrmann, L., Zamarian, L., Auer, F., Mitterling, T., Gabelia, D., Brandauer, E., Delazer, M., Poewe, W. and Högl, B. (2012), Validation of the Innsbruck REM sleep behavior disorder inventory. Mov. Disord., 27: 1673–1678. doi: 10.1002/mds.25223
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 28 NOV 2012
- Article first published online: 28 NOV 2012
- Manuscript Accepted: 30 AUG 2012
- Manuscript Revised: 14 AUG 2012
- Manuscript Received: 28 JUN 2012
- REM sleep behavior disorder;
- screening questionnaire;
A diagnosis of definite REM sleep behavior disorder requires both a positive history for REM sleep behavior disorder and polysomnographic demonstration of REM sleep without atonia. To improve and facilitate screening for REM sleep behavior disorder, there is a need for simple clinical tools with sufficient sensitivity and specificity for the identification of subjects with probable REM sleep behavior disorder. We developed a short REM sleep behavior disorder screening questionnaire with 7 REM sleep behavior disorder– and 2 non-REM sleep behavior disorder–specific control items and performed a validation study in 70 REM sleep behavior disorder subjects and 140 sleep disorder controls. Response patterns to all 7 REM sleep behavior disorder–specific items differed between REM sleep behavior disorder and non-REM sleep behavior disorder patients (all P < 0.05), whereas the 2 non-REM sleep behavior disorder–specific control items did not differentiate between REM sleep behavior disorder and non-REM sleep behavior disorder (all P > .05). In 5 of the 7 REM sleep behavior disorder–specific items, AUC was greater than 0.700. These 5 items were included in the Innsbruck REM sleep behavior disorder inventory. In this questionnaire, a cutoff of 0.25 (number of positive symptoms divided by number of answered questions) had a sensitivity of 0.914 and a specificity of 0.857 for both idiopathic and Parkinson's-related REM sleep behavior disorder (AUC, 0.886). The Innsbruck REM sleep behavior disorder inventory is a promising, easy-to-use, short screening tool for REM sleep behavior disorder with excellent sensitivity and specificity for both idiopathic and Parkinson's-related REM sleep behavior disorder. © 2012 Movement Disorder Society