Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 31 OCT 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 14, pages 1823–1826, December 2012
How to Cite
Mata, I. F., Checkoway, H., Hutter, C. M., Samii, A., Roberts, J. W., Kim, H. M., Agarwal, P., Alvarez, V., Ribacoba, R., Pastor, P., Lorenzo-Betancor, O., Infante, J., Sierra, M., Gómez-Garre, P., Mir, P., Ritz, B., Rhodes, S. L., Colcher, A., Van Deerlin, V., Chung, K. A., Quinn, J. F., Yearout, D., Martinez, E., Farin, F. M., Wan, J. Y., Edwards, K. L. and Zabetian, C. P. (2012), Common variation in the LRRK2 gene is a risk factor for Parkinson's disease. Mov. Disord., 27: 1823–1826. doi: 10.1002/mds.25226
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 31 DEC 2012
- Article first published online: 31 OCT 2012
- Manuscript Accepted: 6 SEP 2012
- Manuscript Revised: 22 AUG 2012
- Manuscript Received: 27 JUN 2012
- Parkinson's disease;
Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear.
We genotyped 66 LRRK2 tagging single-nucleotide polymorphisms (SNPs) in 575 PD patients and 689 controls from the northwestern United States (tier 1). PD-associated SNPs (P < .05) were then genotyped in an independent sample of 3617 cases and 2512 controls from the United States and Spain (tier 2). Logistic regression was used to model additive SNP genotype effects adjusted for age and sex among white individuals.
Two regions showed independent association with PD in tier 1, and SNPs in both regions were successfully replicated in tier 2 (rs10878226, combined odds ratio [OR], 1.20; 95% confidence interval [CI], 1.08–1.33; P = 6.3 × 10−4; rs11176013, OR, 0.89; CI, 0.83–0.95; P = 4.6 × 10−4).
Our data suggest that common variation within LRRK2 conveys susceptibility for PD in individuals of European ancestry. © 2012 Movement Disorder Society