Funding agencies: This study was supported by Generalitat de Catalunya (2009SGR0836 [to E.T.] and 2009SGR0941 [to C. J.]), PSI2010-16174 (to C.J.), and CIBERNED (to N.I.-B.).
Article first published online: 2 NOV 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 14, pages 1746–1753, December 2012
How to Cite
Ibarretxe-Bilbao, N., Junque, C., Segura, B., Baggio, H. C., Marti, M. J., Valldeoriola, F., Bargallo, N. and Tolosa, E. (2012), Progression of cortical thinning in early Parkinson's disease. Mov. Disord., 27: 1746–1753. doi: 10.1002/mds.25240
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 31 DEC 2012
- Article first published online: 2 NOV 2012
- Manuscript Accepted: 16 SEP 2012
- Manuscript Revised: 3 AUG 2012
- Manuscript Received: 16 JAN 2012
- Parkinson's disease;
- cortical thickness
The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process. © 2012 Movement Disorder Society