Progression of cortical thinning in early Parkinson's disease§

Authors

  • Naroa Ibarretxe-Bilbao PhD,

    1. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    2. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    3. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
    4. Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Basque Country, Bilbao, Spain
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  • Carme Junque PhD,

    Corresponding author
    1. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    2. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    3. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
    • Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Casanova 143, 08036 Barcelona, Spain

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  • Barbara Segura PhD,

    1. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    2. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    3. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
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  • Hugo C. Baggio MD,

    1. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    2. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    3. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
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  • Maria J. Marti MD, PhD,

    1. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    2. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    3. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Catalonia, Spain
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  • Francesc Valldeoriola MD, PhD,

    1. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    2. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    3. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Catalonia, Spain
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  • Nuria Bargallo MD, PhD,

    1. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    2. Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona, Hospital Clínic de Barcelona, Catalonia, Spain
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  • Eduardo Tolosa MD, PhD

    1. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    2. Institute of Biomedical Research August Pi i Sunyer, Catalonia, Spain
    3. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Catalonia, Spain
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  • Funding agencies: This study was supported by Generalitat de Catalunya (2009SGR0836 [to E.T.] and 2009SGR0941 [to C. J.]), PSI2010-16174 (to C.J.), and CIBERNED (to N.I.-B.).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process. © 2012 Movement Disorder Society

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