Funding agencies: This study was supported by the University of Sydney.
Article first published online: 9 NOV 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 14, pages 1811–1815, December 2012
How to Cite
Tawadros, P. B., Cordato, D., Cathers, I. and Burne, J. A. (2012), An electromyographic study of parkinsonian swallowing and its response to levodopa. Mov. Disord., 27: 1811–1815. doi: 10.1002/mds.25262
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 31 DEC 2012
- Article first published online: 9 NOV 2012
- Manuscript Accepted: 27 SEP 2012
- Manuscript Revised: 5 SEP 2012
- Manuscript Received: 18 MAR 2012
- idiopathic Parkinson's disease;
Few studies have investigated the effect of levodopa on parkinsonian swallowing with findings thus far being equivocal.
We used surface electromyography and accelerometry to investigate submental and laryngeal muscle activation during swallowing in 14 parkinsonian subjects before and after levodopa and in 22 age-matched controls. Our aims were (1) to demonstrate the clinical utility of noninvasive electromyography, (2) to identify electromyographic features of parkinsonian swallowing, and (3) to investigate the effect of levodopa on parkinsonian swallowing.
The parkinsonian group showed increased burst amplitudes and durations and increased swallow duration, clearing activity and latency between submental and laryngeal bursts (P < .05) and used more swallows than did controls to consume water boluses (P < .001). Levodopa decreased the latency between submental and laryngeal bursts (P < .05) but did not produce effects on individual muscle bursts.
The clinical utility of electrophysiological and biomechanical methods of swallowing assessment was demonstrated. Levodopa tended to normalize the timing of the combined swallow response but not the activity of individual muscles. © 2012 Movement Disorder Society