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Brief Reports

Caffeine consumption and risk of dyskinesia in CALM-PD

  1. Anne-Marie A. Wills MD, MPH1,
  2. Shirley Eberly MS2,
  3. Marsha Tennis RN1,
  4. Anthony E. Lang MD3,
  5. Susan Messing2,
  6. Daniel Togasaki MD4,
  7. Caroline M. Tanner MD, PhD5,
  8. Cornelia Kamp MBA6,
  9. Jiang-Fan Chen MD, PhD7,
  10. David Oakes PhD2,
  11. Michael P. McDermott PhD2,6,
  12. Michael A. Schwarzschild MD, PhD1,*,
  13. on behalf of the Parkinson Study Group

Article first published online: 21 JAN 2013

DOI: 10.1002/mds.25319

Issue

Movement Disorders

Movement Disorders

Volume 28, Issue 3, pages 380–383, March 2013

Additional Information

How to Cite

Wills, A.-M. A., Eberly, S., Tennis, M., Lang, A. E., Messing, S., Togasaki, D., Tanner, C. M., Kamp, C., Chen, J.-F., Oakes, D., McDermott, M. P., Schwarzschild, M. A. and on behalf of the Parkinson Study Group (2013), Caffeine consumption and risk of dyskinesia in CALM-PD. Mov. Disord., 28: 380–383. doi: 10.1002/mds.25319

Author Information

  1. 1

    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA

  2. 2

    Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA

  3. 3

    Department of Medicine, Division of Neurology, University of Toronto, Edmond J. Safra Program in Parkinson's Disease University Health Network, Toronto, Ontario, Canada

  4. 4

    Department of Neurology, University of Southern California, Los Angeles, California, USA

  5. 5

    Parkinson's Institute, Sunnyvale, California, USA

  6. 6

    Department of Neurology, Center for Human Experimental Therapeutics, University of Rochester, Rochester, New York, USA

  7. 7

    Molecular Neuropharmacology Laboratory, Boston University, Boston, Massachusetts, USA

*Correspondence to: Dr. Michael Schwarzschild, MassGeneral Institute for Neurodegenerative Disease, 114 16th Street, Boston, MA 02129, USA; michaels@helix.mgh.harvard.edu

  1. Funding agencies: The study was supported by the Michael J. Fox Foundation for Parkinson's Research Fast Track 2001 Program, the Parkinson's Disease Foundation, and NIH grants R01NS054978 and K24NS60991.

  2. Relevant conflicts of interest/financial disclosures: The present study is a secondary analysis of the database of a clinical trial, CALM-PD, and its extension study, CALM Cohort, which were sponsored by Pharmacia Corporation (Peapack, NJ) and Boehringer Ingelheim (Ingelheim, Germany). In January 2001 Pharmacia approved an investigator (Michael A. Schwarzschild)–initiated proposal to introduce an add-on caffeine questionnaire to CALM-PD subjects to test our prespecified hypotheses that higher caffeine consumption is associated with lower rates of dyskinesia development and/or disease progression. Neither Pharmacia nor Boehringer Ingelheim provided funding for or otherwise supported or participated in the present study. Anne-Marie A. Wills participates in the Schering-Plough-sponsored clinical trials of Preladenant and has served as a consultant for Accordant (a CVS/Caremark disease management company), for Asubio Pharmaceuticals, and for NanoDerma Ltd. Shirley Eberly has received research support from the NIH, DOD, Michael J Fox Foundation, Parkinson's Disease Foundation, Cephalon, and Lundbeck. Anthony E. Lang has served as an adviser for Abbott, Allon Therapeutics, Astra Zenica, Avanir Pharmaceuticals, Biovail, Boerhinger-Ingelheim, Cephalon, Ceregene, Eisai, GSK, Lundbeck A/S, Medtronic, Merck Serono, Novartis, Santhera, Solvay, and Teva; has received honoraria from Teva; has received grants from the Canadian Institutes of Health Research, Dystonia Medical Research Foundation, Michael J. Fox Foundation, National Parkinson Foundation, and Ontario Problem Gambling Research Centre; received publishing royalties from Saunders, Wiley-Blackwell, Johns Hopkins Press, and Cambridge University Press; and has served as an expert witness in cases related to the welding industry. Daniel M. Togasaki participated in the Schering-Plough-sponsored open-label extension study of Preladenant. Caroline M. Tanner is an employee of the Parkinson's Institute; serves on the Scientific Advisory Boards of the Michael J. Fox Foundation and the National Spasmodic Dystonia Association; has provided consulting services to Impax Pharmaceuticals and Adamas Pharmaceuticals; has received grant support from the Michael J. Fox Foundation, the Brin Foundation, James and Sharron Clark, the Parkinson's Institute and Clinical Center, the Parkinson's Disease Foundation, USAMRAA (TATRC managed NETRP Program), National Institute of Neurological Disorders and Stroke (NINDS), and the Agency for Healthcare and Research Quality (AHRQ). Cornelia Kamp is supported by research grants from NINDS, the Michael J. Fox Foundation, and the Friedreich's Ataxia Research Alliance. Jiang-Fan Chen has served as a consultant for Kyowa Pharmaceutical, Inc., and Adenosine Therapeutics. David Oakes has received support from the NIH, the Department of Defense, and the Michael J. Fox Foundation for his research into Parkinson's disease and has received an honorarium from Novo Nordisk Inc. for consulting about an unrelated topic. Michael P. McDermott received research grants from the NIH, FDA, CDC, Muscular Dystrophy Association, SMA Foundation, Michael J. Fox Foundation, Boehringer-Ingelheim Pharmaceuticals, Inc., NeuroSearch Sweden AB, and Medivation, Inc., and served as a consultant for the NY State Department of Health, Pfizer, Inc., Smith and Nephew, Inc., Synosia, Inc., Teva Pharmaceutical Industries, Ltd., Impax Pharmaceuticals, and Bioness, Inc.

  3. Full financial disclosures and author roles may be found in the online version of this article.

Publication History

  1. Issue published online: 21 MAR 2013
  2. Article first published online: 21 JAN 2013
  3. Manuscript Accepted: 12 NOV 2012
  4. Manuscript Revised: 24 OCT 2012
  5. Manuscript Received: 29 JUN 2012

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