A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease

Authors

  • The Huntington Study Group HART Investigators


  • Trial Registration: clinicaltrials.gov Identifier: NCT00724048.

  • Relevant conflicts of interest/financial disclosures: Per Huntington Study Group (HSG) guidelines, no steering committee member, investigator, or coordinator had a personal financial relationship with Neurosearch.

  • Full financial disclosures may be found in the online version of the article. A complete acknowledgment list for The Huntington Study Group HART Investigators may be found in the Appendix.

Correspondence to: Dr. Karl D. Kieburtz, 265 Crittenden Boulevard, CU 420694, Rochester, New York 14642, USA; Karl.Kieburtz@chet.rochester.edu

ABSTRACT

We examined the effects of 3 dosages of pridopidine, a dopamine-stabilizing compound, on motor function and other features of Huntington's disease, with additional evaluation of its safety and tolerability. This was a randomized, double-blind, placebo-controlled trial in outpatient neurology clinics at 27 sites in the United States and Canada. Two hundred twenty-seven subjects enrolled from October 24, 2009, to May 10, 2010. The intervention was pridopidine, either 20 (n=56), 45 (n=55), or 90 (n=58) mg daily for 12 weeks or matching placebo (n=58). The primary outcome measure was the change from baseline to week 12 in the Modified Motor Score, a subset of the Unified Huntington's Disease Rating Scale Total Motor Score. Measures of safety and tolerability included adverse events and trial completion on the assigned dosage. After 12 weeks, the treatment effect (relative to placebo, where negative values indicate improvement) of pridopidine 90 mg/day on the Modified Motor Score was −1.2 points (95% confidence interval [CI], −2.5 to 0.1 points; P = .08). The effect on the Total Motor Score was −2.8 points (95% CI, −5.4 to −0.1 points; nominal P = .04). No significant effects were seen in secondary outcome measures with any of the active dosages. Pridopidine was generally well tolerated. Although the primary analysis did not demonstrate a statistically significant treatment effect, the overall results suggest that pridopidine may improve motor function in Huntington's disease. The 90 mg/day dosage appears worthy of further study. Pridopidine was well tolerated. © 2013 International Parkinson and Movement Disorder Society

Ancillary