Funding agencies: This work was made possible through a generous philanthropic donation from the Vandrevala family.
Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease
Article first published online: 20 MAR 2013
Copyright © 2013 Movement Disorder Society
Volume 28, Issue 8, pages 1146–1149, July 2013
How to Cite
Chahine, L. M., Daley, J., Horn, S., Colcher, A., Hurtig, H., Cantor, C. and Dahodwala, N. (2013), Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease. Mov. Disord., 28: 1146–1149. doi: 10.1002/mds.25438
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the Acknowledgments section online.
- Issue published online: 12 AUG 2013
- Article first published online: 20 MAR 2013
- Manuscript Accepted: 27 JAN 2013
- Manuscript Revised: 9 JAN 2013
- Manuscript Received: 22 SEP 2012
- Parkinson's disease;
- REM sleep behavior disorder
Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach.
The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo questionnaire were prospectively validated.
Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%–100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n = 65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%–92.6%).
A combination of patient and bed-partner questionnaires is a useful tool to detect RBD. © 2013 Movement Disorder Society