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Plasma urate in REM sleep behavior disorder

Authors

  • Reinaldo Uribe-San Martín MD,

    1. Department of Neurology, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile
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  • Pablo Venegas Francke MD,

    1. Department of Neurology, School of Medicine, Universidad de Chile, Santiago, Chile
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  • Felipe López Illanes MD,

    1. Department of Neurology, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile
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  • Alex Jones Gazmuri MD,

    1. Department of Neurology, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile
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  • Julio Salazar Rivera MD, PhD,

    1. Department of Neurology, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile
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  • Jaime Godoy Ferńndez MD,

    1. Department of Neurology, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile
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  • Julia Santín Martínez MD,

    1. Department of Neurology, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile
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  • Carlos Juri MD, PhD

    Corresponding author
    1. Department of Neurology, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile
    2. Department of Neurology, Hospital Sotero del Río, Santiago, Chile
    • Correspondence to: Dr. C. Juri, Neurology Department, School of Medicine, Pontificia Universidad Católica de Chile, Marcoleta 350, 2nd Floor, Santiago, Chile; cjuri@med.puc.cl

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  • Funding agencies: This study was supported by Pontificia Universidad Católica de Chile School of Medicine.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the Acknowledgments section online.

ABSTRACT

Background

Rapid eye movement (REM) sleep behavior disorder (RBD) is associated with a high risk of developing Parkinson's disease (PD). Higher urate levels are associated with a lower risk of PD. We conducted a study to evaluate plasma urate levels in patients with RBD and their role in the development of PD.

Methods

We evaluated plasma urate levels in a cohort of 24 patients with idiopathic RBD. Patients were divided into 2 groups according to the presence or absence of PD. Other known markers of the risk of developing PD, such as olfaction testing, and substantia nigra (SN) hyperechogenicity, were evaluated in the 2 groups.

Results

No differences were observed regarding age, years of evolution of the RBD, SN hyperechogenicity, or plasma urate levels between the 2 groups. In patients without PD, there was a positive correlation between years of evolution of RBD and the levels of uric acid (R2 = 0.88). Patients without PD and those who had more than 5 years of RBD exhibited higher levels of uric acid than patients with PD (P = 0.02).

Conclusions

Higher levels of plasma urate were associated with a longer duration of RBD without converting to PD. Future prospective studies would be needed to confirm this finding. Disorder Society.© 2013 Movement Disorder Society

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