Relevant conflicts of interest/financial disclosures: Nothing to report.
Bilateral pallidal stimulation for Wilson's disease
Article first published online: 3 APR 2013
Copyright © 2013 Movement Disorder Society
Volume 28, Issue 9, pages 1292–1295, August 2013
How to Cite
Sidiropoulos, C., Hutchison, W., Mestre, T., Moro, E., Prescott, I. A., Mizrachi, A. V., Fallis, M., Rughani, A. I., Kalia, S. K., Lozano, A. and Fox, S. (2013), Bilateral pallidal stimulation for Wilson's disease. Mov. Disord., 28: 1292–1295. doi: 10.1002/mds.25446
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 3 SEP 2013
- Article first published online: 3 APR 2013
- Manuscript Accepted: 22 FEB 2013
- Manuscript Revised: 13 FEB 2013
- Manuscript Received: 16 JAN 2013
- deep brain stimulation;
- globus pallidus;
- Wilson's disease
To report on the clinical efficacy of bilateral globus pallidus internus deep brain stimulation in a 29-year-old patient with severe generalized dystonia secondary to Wilson's disease.
The primary outcome measure was the Burke-Fahn-Marsden Dystonia Scale motor severity score (blinded assessment) and the secondary outcome measures were the Abnormal Involuntary Movement Scale (blinded assessment) and the Zaritt Caregiver Burden Interview score, at 20-week postoperative follow up.
There was a 14% improvement in the Burke-Fahn-Marsden Dystonia Scale motor severity score. Abnormal Involuntary Movement Scale score remained unchanged while the Zaritt Caregiver Burden Interview score improved by 44.4%.
Bilateral globus pallidus deep brain stimulation can be effective in ameliorating dystonia and caregiver burden in Wilson's disease. Outcomes may depend on the stage of the disease at which the surgical procedure is completed. © 2013 Movement Disorder Society