Funding agencies: The work was supported by Parkinson's NSW (scholarship to Stefanie Reyes); Neuroscience Research Australia (Elizabeth and Michael Gilbert scholarship to Stefanie Reyes); the Swedish Research Council (K2009-61P-20945-03-1 to Deniz Kirik); the “Verein zur Durchführung Neurowissenschaftlicher Tagungen e. V.,” Berlin, Germany (to Kay L. Double); the National Health & Medical Research Council of Australia (630434 to Glenda M. Halliday); and the Australian Research Council (LE100100074 to Glenda M. Halliday).
Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra
Article first published online: 14 MAY 2013
© 2013 International Parkinson and Movement Disorder Society
Volume 28, Issue 10, pages 1351–1359, September 2013
How to Cite
Reyes, S., Cottam, V., Kirik, D., Double, K. L. and Halliday, G. M. (2013), Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Mov. Disord., 28: 1351–1359. doi: 10.1002/mds.25493
Relevant conflicts of interest/financial disclosures: Nothing to report.
- Issue published online: 23 SEP 2013
- Article first published online: 14 MAY 2013
- Manuscript Accepted: 3 APR 2013
- Manuscript Revised: 1 APR 2013
- Manuscript Received: 20 OCT 2012
Additional Supporting Information may be found in the online version of this article.
|mds25493-sup-0001-suppfig1.tif||8662K||SUPPLEMENTARY FIG 1. Low-magnification photomicrographs showing the cytoarchitectural distribution of the dopaminergic cell groups identified using tyrosine hydroxylase immunohistochemistry at the 3 rostrocaudal levels of the human midbrain. These levels were identified in each case and adjacent section double-labeled and assessed for fluorescence intensity analysis as detailed in the Patients and Methods section. The most caudal level (C) was at the decussation of the superior cerebellar peduncle (xscp). An intermediate level (B) where the greatest number of exiting third-nerve fibers occurred was assessed. The most consistent rostral level (A) was just below the opening of the aqueduct into the third ventricle at the greatest cross-sectional extent of the red nucleus. At this rostral level there were many ascending tyrosine hydroxylase immunopositive axons in the medial aspects of the midbrain. Scale in C is equivalent for A and B (cp, cerebral peduncle; R, red nucleus; SNC, substantia nigra pars compacta; VTA, ventral tegmental area).|
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