Lack of polysomnographic Non-REM sleep changes in early Parkinson's disease

Authors

  • Nico J. Diederich MD,

    Corresponding author
    1. Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg
    2. Interdisciplinary Sleep Laboratory, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg
    3. Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg
    • Correspondence to: Dr. Nico Diederich, Centre Hospitalier de Luxembourg, 4, rue Barblé, L-1210-Luxembourg-City, Luxembourg; diederdn@pt.lu

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  • Olivier Rufra RN,

    1. Interdisciplinary Sleep Laboratory, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg
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  • Vannina Pieri MS,

    1. Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg
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  • Géraldine Hipp MS,

    1. Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg
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  • Michel Vaillant PhD

    1. Methodology and Statistical Unit, CRP-Santé, Strassen, Luxembourg
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  • Funding agencies: This study was supported by the Fonds National de Recherche (FNR/06/04/05), the Luxembourg Parkinson Association, and the Fondation Think, Luxembourg.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson's disease (IPD).

Methods

Thirty-three patients who had IPD with a disease duration ≤3 years and 37 age-matched controls were recruited. PSG analysis was performed on current medication.

Results

Patients with IPD had a reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P < 0.05). Total sleep time, sleep efficiency, indices/hour of arousals, awakenings, apnea/hypopnea, and periodic leg movements were similar in both groups. Age, but not dopaminergic medication, had a negative impact on sleep architecture in patients with IPD. There was no correlation between sleep efficiency assessed by PSG and sleep quality assessed by questionnaire.

Conclusions

The results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage. © 2013 International Parkinson and Movement Disorder Society

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