Funding agencies: This study was supported by the Fonds National de Recherche (FNR/06/04/05), the Luxembourg Parkinson Association, and the Fondation Think, Luxembourg.
Lack of polysomnographic Non-REM sleep changes in early Parkinson's disease
Article first published online: 6 JUN 2013
© 2013 The Authors. Movement Disorders published by Wiley on behalf of the International Parkinson and Movement Disorder Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 28, Issue 10, pages 1443–1446, September 2013
How to Cite
Diederich, N. J., Rufra, O., Pieri, V., Hipp, G. and Vaillant, M. (2013), Lack of polysomnographic Non-REM sleep changes in early Parkinson's disease. Mov. Disord., 28: 1443–1446. doi: 10.1002/mds.25520
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 23 SEP 2013
- Article first published online: 6 JUN 2013
- Manuscript Accepted: 22 APR 2013
- Manuscript Revised: 10 APR 2013
- Manuscript Received: 9 OCT 2012
- Parkinson's disease;
- REM sleep behavior disorder;
- sleep questionnaire
Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson's disease (IPD).
Thirty-three patients who had IPD with a disease duration ≤3 years and 37 age-matched controls were recruited. PSG analysis was performed on current medication.
Patients with IPD had a reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P < 0.05). Total sleep time, sleep efficiency, indices/hour of arousals, awakenings, apnea/hypopnea, and periodic leg movements were similar in both groups. Age, but not dopaminergic medication, had a negative impact on sleep architecture in patients with IPD. There was no correlation between sleep efficiency assessed by PSG and sleep quality assessed by questionnaire.
The results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage. © 2013 International Parkinson and Movement Disorder Society