Relevant conflicts of interest/financial disclosures: Nothing to report.
Gait ataxia—specific cerebellar influences and their rehabilitation
Article first published online: 16 OCT 2013
© 2013 Movement Disorder Society
Special Issue: Gait and Balance in Movement Disorders
Volume 28, Issue 11, pages 1566–1575, 15 September 2013
How to Cite
Ilg, W. and Timmann, D. (2013), Gait ataxia—specific cerebellar influences and their rehabilitation. Mov. Disord., 28: 1566–1575. doi: 10.1002/mds.25558
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 16 OCT 2013
- Article first published online: 16 OCT 2013
- Manuscript Accepted: 10 MAY 2013
- Manuscript Revised: 6 MAY 2013
- Manuscript Received: 28 FEB 2013
It is well known that the cerebellum is important for movement control and plays a critical role in balance and locomotion. As such, one of the most characteristic and sensitive signs of cerebellar damage is gait ataxia. However, characterizing ataxic gait is no easy task, because gait patterns are highly variable. This variability seems to result from the interaction of different factors, namely, (1) the primary motor deficits in balance control and multi-joint coordination and oculomotor dysfunction, (2) the safety strategies used, and (3) inaccurate adjustments in patients with loss of balance. In this report, we review different approaches to analyzing ataxic gait and studies to identify and quantify the different factors contributing to this movement disorder. We also discuss the influence of the cerebellum in adaptive locomotor control, the interaction between cognitive load and gait in dual-task paradigms, and the recent advances in rehabilitation of gait and posture for patients with cerebellar degeneration. In the second part, we discuss open questions concerning cerebellar mechanisms in multi-joint coordination during different walking conditions. Furthermore, we point out potential future directions in motor rehabilitation, with the objective of identifying predictors of rehabilitation outcome and the development of individualized training programs that potentially involve rehabilitation technology. © 2013 International Parkinson and Movement Disorder Society