Dr. Witt and Dr. Moro contributed equally to this work.
Predictive factors of outcome in primary cervical dystonia following pallidal deep brain stimulation
Article first published online: 20 JUN 2013
© 2013 International Parkinson and Movement Disorder Society
Volume 28, Issue 10, pages 1451–1455, September 2013
How to Cite
Witt, J. L., Moro, E., Ash, R. S., Hamani, C., Starr, P. A., Lozano, A. M., Hodaie, M., Poon, Y.-Y., Markun, L. C. and Ostrem, J. L. (2013), Predictive factors of outcome in primary cervical dystonia following pallidal deep brain stimulation. Mov. Disord., 28: 1451–1455. doi: 10.1002/mds.25560
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 23 SEP 2013
- Article first published online: 20 JUN 2013
- Manuscript Accepted: 9 MAY 2013
- Manuscript Revised: 7 MAY 2013
- Manuscript Received: 20 NOV 2012
- globus pallidus;
- deep brain stimulation;
- cervical dystonia
Improvement after bilateral globus pallidus internus deep brain stimulation (DBS) in primary generalized dystonia has been negatively associated with disease duration and age, but no predictive factors have been identified in primary cervical dystonia (CD).
Patients treated with bilateral globus pallidus internus DBS for primary CD from 2 DBS centers with preoperative and postoperative Toronto Western Spasmodic Torticollis Rating Scales (TWSTRS) were studied retrospectively to explore possible predictors of response.
Patients showed significantly improved TWSTRS total and severity scores (n = 28, mean 55.6% and 50.8%, respectively, both P < .001). Patients with lateral shift at baseline had less improvement in TWSTRS severity subscores (P = .02). No correlations between outcomes and disease duration, age at dystonia onset or surgery, baseline scores, or other included variables were found.
Although this is the largest study supporting efficacy of bilateral pallidal DBS in primary CD, no major clinical predictive outcomes of surgical benefit were identified. © 2013 International Parkinson and Movement Disorder Society