Additional Supporting Information may be found in the online version of this article.

mds25561-sup-0001-suppfig1.eps1421KSUPPORTING FIG. 1. The study design is illustrated. Enrolled patients were randomized to receive 20 mg/day, 50 mg/day, 100 mg/day, 150 mg/day, or 200 mg/day AFQ056 or placebo (1:1:1:1:2:3 ratio) in a 12-week, double-blind treatment phase. Patients were titrated at 1-week intervals to their target or highest tolerated dose. With the exception of the 20 mg/day AFQ056 group, all active-treated patients were initiated on 50 mg/day AFQ056. At the beginning of week 13, active-treated patients were randomized to a 1-week taper-off regimen with AFQ056 or placebo. The 20 mg/day AFQ056 group received 20 mg/day AFQ056 or placebo for 1 week, and the 50 mg/day AFQ056 group received 50 mg/day AFQ056 or placebo for 1 week. The 100 mg/day, 150 mg/day, and 200 mg/day AFQ056 groups received either 100 mg/day AFQ056 for 3 days followed by 50 mg/day AFQ056 for 4 days (1 week total duration) or placebo for 1 week.
mds25561-sup-0002-supptab1.doc32KSupporting Table 1. Summary of the final actual dose of AFQ056 received at the end of the treatment phase, by randomized dose
mds25561-sup-0003-suppinfo.doc54KSupporting Information.

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