Chunyan Cao and Yixin Pan contributed equally to this work.
Subthalamus deep brain stimulation for primary dystonia patients: A long-term follow-up study
Article first published online: 16 JUL 2013
© 2013 Movement Disorder Society
Volume 28, Issue 13, pages 1877–1882, November 2013
How to Cite
Cao, C., Pan, Y., Li, D., Zhan, S., Zhang, J. and Sun, B. (2013), Subthalamus deep brain stimulation for primary dystonia patients: A long-term follow-up study. Mov. Disord., 28: 1877–1882. doi: 10.1002/mds.25586
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 13 NOV 2013
- Article first published online: 16 JUL 2013
- Manuscript Accepted: 29 MAY 2013
- Manuscript Revised: 15 MAY 2013
- Manuscript Received: 29 OCT 2012
- primary dystonia;
- subthalamic nucleus;
- deep brain stimulation;
- Burke–Fahn–Marsden dystonia rating scale;
- Medical Outcomes Study 36-item Short-Form General Health Survey
Deep brain stimulation has generated sustained improvement in motor function for patients with dystonia, but the long-term impact of subthalamic nucleus stimulation on dystonia has not been elucidated.
Patients with primary dystonia underwent bilateral subthalamic nucleus stimulation and were evaluated with the Burke–Fahn–Marsden dystonia rating scale and the Medical Outcomes Study 36-item Short-Form General Health Survey at baseline and 1 month, 1 year, and 3 to 10 years postoperatively.
Improvements in motor function according to the Burke–Fahn–Marsden dystonia rating scale at 1 month, 1 year, and 3 to 10 years of stimulation were 55%, 77%, and 79%, respectively. The quality of life improved after 1 month of stimulation (P < 0.001), progressed within 1 year (P < 0.001), and then remained stable. Disease duration was negatively correlated with an improvement in motor function.
Our results demonstrate that the subthalamus is an alternative to the globus pallidus internus as a target for deep brain stimulation to treat primary dystonia. © 2013 International Parkinson and Movement Disorder Society