Funding agencies: This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada, the Canadian Institutes of Health Research, and the National Institutes of Health (NIDCD-R01DC012502).
Sensorimotor adaptation of speech in Parkinson's disease
Article first published online: 16 JUL 2013
© 2013 Movement Disorder Society
Volume 28, Issue 12, pages 1668–1674, October 2013
How to Cite
Mollaei, F., Shiller, D. M. and Gracco, V. L. (2013), Sensorimotor adaptation of speech in Parkinson's disease. Mov. Disord., 28: 1668–1674. doi: 10.1002/mds.25588
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 25 OCT 2013
- Article first published online: 16 JUL 2013
- Manuscript Accepted: 10 MAY 2013
- Manuscript Revised: 19 MAR 2013
- Manuscript Received: 19 DEC 2012
- sensorimotor adaptation;
- speech production;
- Parkinson's disease;
- speech motor learning;
- auditory feedback
The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force-field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age-matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society