Sensorimotor adaptation of speech in Parkinson's disease

Authors

  • Fatemeh Mollaei BA,

    1. Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada
    2. School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada
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  • Douglas M. Shiller PhD,

    1. Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada
    2. CHU Sainte-Justine Research Center, Montreal, Quebec, Canada
    3. École d'Orthophonie et d'Audiologie, Université de Montréal, Montreal, Quebec, Canada
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  • Vincent L. Gracco PhD

    Corresponding author
    1. Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada
    2. School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada
    3. Haskins Laboratories, New Haven, Connecticut, USA
    • Correspondence to: Dr. Vincent L. Gracco, Centre for Research on Brain, Language & Music, McGill University, 3640 de la Montagne, Montreal, Quebec, H3G2A8, Canada; vincent.gracco@mcgill.ca

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  • Funding agencies: This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada, the Canadian Institutes of Health Research, and the National Institutes of Health (NIDCD-R01DC012502).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force-field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age-matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society

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