Relevant conflicts of interest/financial disclosures: Nothing to report.
Short sleep duration heralds essential tremor: A prospective, population-based study
Article first published online: 11 JUL 2013
© 2013 Movement Disorder Society
Volume 28, Issue 12, pages 1700–1707, October 2013
How to Cite
Benito-León, J., Louis, E. D. and Bermejo-Pareja, F. (2013), Short sleep duration heralds essential tremor: A prospective, population-based study. Mov. Disord., 28: 1700–1707. doi: 10.1002/mds.25590
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 25 OCT 2013
- Article first published online: 11 JUL 2013
- Manuscript Accepted: 4 JUN 2013
- Manuscript Revised: 24 MAY 2013
- Manuscript Received: 13 FEB 2013
- incident essential tremor;
- sleep duration
Lewy bodies have been described in the locus coeruleus of some patients with essential tremor (ET), and this brainstem nucleus plays an important role in sleep cycle regulation. Despite this, no studies have investigated the relationship between daily sleep duration and the risk of ET. We determined whether baseline daily sleep duration was associated with an increased risk of incident ET. In this prospective, population-based study of individuals > 65 years of age (the Neurological Disorders in Central Spain [NEDICES] cohort), participants were evaluated at baseline and 3 years later. At baseline, participants indicated their daily sleep duration as the sum of nighttime sleep and daytime napping. The average daily total sleep duration was grouped into four categories: ≤ 5 hours (short sleepers), 6 hours, 7 to 8 hours (reference), and ≥ 9 hours (long sleepers) hours. In total, 3,303 participants had a median duration of follow-up of 3.3 years. There were 76 incident ET cases at follow-up. The relative risks for short sleepers and for long sleepers were 2.25 (95% confidence interval [CI], 1.21-4.16; P = 0.01) and 0.74 (95% CI, 0.41-1.32; P = 0.31), respectively. After adjustment for potential confounders, including age, sex, educational level, current smoker, current drinker, and depressive symptoms or antidepressant use, the risk remained significantly increased for short sleepers (relative risk, 1.95; 95% CI, 1.03-3.70; P = 0.04]). The results indicated that short daily sleep duration may be a pre-motor marker for ET. Additional prospective studies are needed to confirm these results, and the biological basis for this association merits additional investigation. © 2013 International Parkinson and Movement Disorder Society