Drs. Liu and Xiao contributed equally to this work.
Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China
Article first published online: 12 JUL 2013
© 2013 Movement Disorder Society
Volume 28, Issue 13, pages 1892–1895, November 2013
How to Cite
Liu, J., Xiao, Q., Wang, Y., Xu, Z.-M., Wang, Y., Yang, Q., Wang, G., Tan, Y.-Y., Ma, J.-F., Zhang, J., Huang, W. and Chen, S.-D. (2013), Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China. Mov. Disord., 28: 1892–1895. doi: 10.1002/mds.25599
Funding agencies: This study was supported by grants from the National Program of Basic Research (2010CB945200, 2011CB504104) of China, National Natural Science Fund (81071024, 81171202, 30872729, 30870879 and 81129018), Shanghai Shuguang Program (11SG20), and the Fifth National Undergraduate Student Innovating Program (2011015) and Public Benefit Research Foundation from Ministry of Health (201202008).
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 13 NOV 2013
- Article first published online: 12 JUL 2013
- Manuscript Accepted: 4 JUN 2013
- Manuscript Revised: 10 APR 2013
- Manuscript Received: 26 NOV 2012
- Parkinson's disease;
- single nucleotide polymorphism;
Genome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) that can modulate the risk of developing Parkinson's disease (PD).
We investigated the association of previously identified loci in a Mainland Chinese population to identify a possible ethnic-specific effect with GWAS analysis. Seventeen SNPs were genotyped from those loci using case–control methodology to analyze a total of 1,737 individuals.
Strong evidence of an association for reference SNP 894278 (rs894278) and rs11931074 on 4q22 throughout the α synuclein (SNCA) region was observed in our study. The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression. The minor allele frequency of rs11724635 produced weaker signals for PD, but this was not replicated in the genotype after adjusting for age and sex.
This study yields new clues about GWAS-linked data in patients with PD from Mainland China. © 2013 International Parkinson and Movement Disorder Society