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Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China

Authors

  • Jun Liu MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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    • Drs. Liu and Xiao contributed equally to this work.

  • Qin Xiao MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Ying Wang PhD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    2. Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Academy of Science and Technology, Shanghai, China
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  • Zhi-Min Xu MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Ying Wang MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Qiong Yang MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Gang Wang MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Yu-Yan Tan MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Jian-Fang Ma MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Jin Zhang MD,

    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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  • Wei Huang PhD,

    Corresponding author
    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    2. Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Academy of Science and Technology, Shanghai, China
    • Correspondence to: Dr. Wei Huang, Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Academy of Science and Technology, Shanghai, 201203, China; weihuangsh@gmail.com or Dr. Sheng-Di Chen, Department of Neurology and Institute of Neurology, Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; chen_sd@medmail.com.cn.

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  • Sheng-Di Chen MD

    Corresponding author
    1. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    • Correspondence to: Dr. Wei Huang, Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Academy of Science and Technology, Shanghai, 201203, China; weihuangsh@gmail.com or Dr. Sheng-Di Chen, Department of Neurology and Institute of Neurology, Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; chen_sd@medmail.com.cn.

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  • Funding agencies: This study was supported by grants from the National Program of Basic Research (2010CB945200, 2011CB504104) of China, National Natural Science Fund (81071024, 81171202, 30872729, 30870879 and 81129018), Shanghai Shuguang Program (11SG20), and the Fifth National Undergraduate Student Innovating Program (2011015) and Public Benefit Research Foundation from Ministry of Health (201202008).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

Genome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) that can modulate the risk of developing Parkinson's disease (PD).

Methods

We investigated the association of previously identified loci in a Mainland Chinese population to identify a possible ethnic-specific effect with GWAS analysis. Seventeen SNPs were genotyped from those loci using case–control methodology to analyze a total of 1,737 individuals.

Results

Strong evidence of an association for reference SNP 894278 (rs894278) and rs11931074 on 4q22 throughout the α synuclein (SNCA) region was observed in our study. The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression. The minor allele frequency of rs11724635 produced weaker signals for PD, but this was not replicated in the genotype after adjusting for age and sex.

Conclusions

This study yields new clues about GWAS-linked data in patients with PD from Mainland China. © 2013 International Parkinson and Movement Disorder Society

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