Funding agencies: This study was supported by the Spanish Ministry of Economy and Competitiveness, Spanish Ministry of Health (RD06/0010/0013 and CIBERNED), Galician Government (XUGA), and FEDER (Regional European Development Fund).
Dopamine-Angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease
Article first published online: 7 AUG 2013
© 2013 International Parkinson and Movement Disorder Society
Volume 28, Issue 10, pages 1337–1342, September 2013
How to Cite
Labandeira-Garcia, J. L., Rodriguez-Pallares, J., Dominguez-Meijide, A., Valenzuela, R., Villar-Cheda, B. and Rodríguez-Perez, A. I. (2013), Dopamine-Angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease. Mov. Disord., 28: 1337–1342. doi: 10.1002/mds.25614
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 23 SEP 2013
- Article first published online: 7 AUG 2013
- Manuscript Accepted: 26 JUN 2013
- Manuscript Revised: 29 APR 2013
- Manuscript Received: 11 JAN 2013
- degenerative disease;
- oxidative stress;
- renin-angiotensin system
Renin-angiotensin systems are known to act in many tissues, for example, the blood vessel wall or kidney, where a close interaction between angiotensin and dopamine has been demonstrated. Regulatory interactions between the dopaminergic and renin-angiotensin systems have recently been described in the substantia nigra and striatum. In animal models, dopamine depletion induces compensatory overactivation of the local renin-angiotensin system, which primes microglial responses and neuron vulnerability by activating NADPH-oxidase. Hyperactivation of the local renin-angiotensin system exacerbates the inflammatory microglial response, oxidative stress, and dopaminergic degeneration, all of which are inhibited by angiotensin receptor blockers and inhibitors of angiotensin-converting enzymes. In this review we provide evidence suggesting that the renin-angiotensin system may play an important role in dopamine's mediated neuroinflammation and oxidative stress changes in Parkinson's disease. We suggest that manipulating brain angiotensin may constitute an effective neuroprotective strategy for Parkinson's disease. © 2013 International Parkinson and Movement Disorder Society