Dopamine-Angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease

Authors

  • Jose L. Labandeira-Garcia MD, PhD,

    Corresponding author
    1. Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain
    • Correspondence to: Dr. Jose L. Labandeira-Garcia, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; joseluis.labandeira@usc.es

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  • Jannette Rodriguez-Pallares PhD,

    1. Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain
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  • Antonio Dominguez-Meijide MSc,

    1. Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain
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  • Rita Valenzuela MSc,

    1. Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain
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  • Begoña Villar-Cheda,

    1. Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain
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  • Ana I. Rodríguez-Perez PhD

    1. Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    2. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain
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  • Funding agencies: This study was supported by the Spanish Ministry of Economy and Competitiveness, Spanish Ministry of Health (RD06/0010/0013 and CIBERNED), Galician Government (XUGA), and FEDER (Regional European Development Fund).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Renin-angiotensin systems are known to act in many tissues, for example, the blood vessel wall or kidney, where a close interaction between angiotensin and dopamine has been demonstrated. Regulatory interactions between the dopaminergic and renin-angiotensin systems have recently been described in the substantia nigra and striatum. In animal models, dopamine depletion induces compensatory overactivation of the local renin-angiotensin system, which primes microglial responses and neuron vulnerability by activating NADPH-oxidase. Hyperactivation of the local renin-angiotensin system exacerbates the inflammatory microglial response, oxidative stress, and dopaminergic degeneration, all of which are inhibited by angiotensin receptor blockers and inhibitors of angiotensin-converting enzymes. In this review we provide evidence suggesting that the renin-angiotensin system may play an important role in dopamine's mediated neuroinflammation and oxidative stress changes in Parkinson's disease. We suggest that manipulating brain angiotensin may constitute an effective neuroprotective strategy for Parkinson's disease. © 2013 International Parkinson and Movement Disorder Society

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