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Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination

Authors


  • Funding agencies: This study was supported by Health and Labor Sciences Research grants for research on measures for intractable diseases and comprehensive research on Aging and Health of the Ministry of Health, Labor and Welfare, Japan.

  • Relevant conflicts of interest/financial disclosures: Watanabe H, Grant-in-Aid for Scientific Research 24591293, Intramural Research Grant (22-7) for Neurological and Psychiatric Disorders of NCNP; Ito M, Grant-in-Aid for Scientific Research 25461313; Senda J, Grant-in-Aid for Scientific Research 25461312; Atsuta N, Grant-in-Aid for Scientific Research 25461277, Grant-in-Aid for Scientific Research on Innovative Areas 22129009; Adachi H, Grant-in-Aid for Scientific Research 23390231, Adaptable and Seamless Technology transfer Program through target-driven R&D; Katsuno M, Grant-in-Aid for Scientific Research 23390230, Grant-in-Aid for Exploratory Research 24659428, Grant-in-Aid for Scientific Research on Innovative Areas 22110005, Core Research for Evolutional Science and Technology (CREST) of the Japan Science and Technology Agency (JST); Naganawa S, Unrestricted educational donation from daiichisankyo and eisai, cooperative research by the public and private sectors (Toshiba Medical Systems Corporation), Grant-in-Aid for Scientific Research, 25293263; Sobue G, Grant-in-Aid for Scientific Research 21229011 and 24300135, Grant-in-Aid for Exploratory Research; Strategic research program for brain sciences, Core Research for Evolutional Science and Technology (CREST) of the Japan Science and Technology Agency (JST), Health and Labour Sciences Research grants and grants-in-Aid for Scientific Research from the MEXT of Japan H23-017. H23-039, H24-012, and H24-014, Research on Applying Health Technology.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

The aim of this study was to investigate the cortical and subcortical brain structures in Parkinson's disease (PD) with visual hallucination (VH), and to elucidate the association between the proposed hypothesis of VH in PD and regional brain volume changes.

Methods

We used 3T magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) to investigate the brain structures of PD patients with VH (PD-VH; n = 13) and PD patients without VH (PD-C; n = 13).

Results

The PD-VH patients showed significant cortical atrophy compared to the PD-C patients in the bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex, bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus. Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus.

Conclusions

VH in PD can occur due to distinctive neuroanatomical involvement. © 2013 International Parkinson and Movement Disorder Society

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