Funding agencies: The study was supported in part by research grants from Taipei Veterans General Hospital (V97ER3-006, VGHUST97-P6-24, V97C1-034, V98C1-095, V98ER3-002, VGH-S4-98-001, VGH-ER3-99-006, V99C1-156, V100C-146, V101C-023, and V102C-101), by grants from the National Science Council (NSC-95-2314-B-010-030-MY3, NSC-96-2628-B-010-030-MY3, NSC-98-2321-B-010-007, NSC-99-2321-B-010-004, NSC-99-2628-B-010-011-MY3, and 101-2314-B-010-068-MY3), and by a grant from the Ministry of Education (Aim for the Top University Plan), Taipei, Taiwan.
Altered inhibitory modulation of somatosensory cortices in paroxysmal kinesigenic dyskinesia
Version of Record online: 20 SEP 2013
© 2013 Movement Disorder Society
Volume 28, Issue 12, pages 1728–1731, October 2013
How to Cite
Hsu, W.-Y., Kwan, S.-Y., Liao, K.-K., Chen, R.-S. and Lin, Y.-Y. (2013), Altered inhibitory modulation of somatosensory cortices in paroxysmal kinesigenic dyskinesia. Mov. Disord., 28: 1728–1731. doi: 10.1002/mds.25656
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 25 OCT 2013
- Version of Record online: 20 SEP 2013
- Manuscript Accepted: 29 JUL 2013
- Manuscript Revised: 11 JUL 2013
- Manuscript Received: 30 JAN 2013
- paroxysmal kinesigenic dyskinesia;
- somatosensory evoked fields;
- paired-pulse inhibition;
- somatosensory cortical inhibition
The objective of this study was to clarify the excitability profiles of the somatosensory cortices in patients with paroxysmal kinesigenic dyskinesia.
Whole-head magnetoencephalography was used to record the somatosensory evoked fields elicited by paired-pulse electric stimulation of the median nerve in 15 patients with paroxysmal kinesigenic dyskinesia and in a control group of 18 age-matched, healthy volunteers. Twelve of the patients were studied in both the drug-off and drug-on state.
The paired-pulse inhibition ratios of the primary somatosensory cortical P35m responses and the secondary somatosensory cortical responses were significantly greater in drug-off patients with paroxysmal kinesigenic dyskinesia compared with either the drug-on patients or the control group. No significant difference in paired-pulse inhibition ratio was observed between the drug-on patients with paroxysmal kinesigenic dyskinesia and the control group.
In patients with paroxysmal kinesigenic dyskinesia, intracortical inhibition of the primary and secondary somatosensory cortical areas is impaired, and the associated hyperexcitable phenomenon is modulatable by antiepileptic drugs. © 2013 International Parkinson and Movement Disorder Society