Funding agencies: This work was funded by the Parkinson's UK Program (grant no.: J-0802) and the Lockhart Parkinson's Disease Research Fund, Newcastle University. The ICICLE-PD study group was funded by Parkinson's UK. This work was also supported by the UK NIHR Biomedical Research Centre for Ageing and Age-related disease and the UK NIHR Biomedical Research Unit in Lewy Body Dementia awards to the Newcastle upon Tyne Hospitals NHS Foundation Trust. Drs. Khoo, Duncan, and Yarnall were supported by the Lockhart Parkinson's Disease Research Fund.
Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms
Article first published online: 7 OCT 2013
© 2013 Movement Disorder Society
Volume 29, Issue 2, pages 195–202, February 2014
How to Cite
Duncan, G. W., Khoo, T. K., Yarnall, A. J., O'Brien, J. T., Coleman, S. Y., Brooks, D. J., Barker, R. A. and Burn, D. J. (2014), Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms. Mov. Disord., 29: 195–202. doi: 10.1002/mds.25664
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 20 FEB 2014
- Article first published online: 7 OCT 2013
- Manuscript Accepted: 12 AUG 2013
- Manuscript Revised: 18 JUL 2013
- Manuscript Received: 22 FEB 2013
- Parkinson's disease;
- non-motor symptoms;
- quality of life;
Nonmotor symptoms (NMS) are common in patients with established Parkinson's disease (PD) and have a major impact upon quality of life. We investigated the significance of NMS in relation to health-related quality of life (HRQoL) in patients with newly diagnosed PD. Patients and healthy controls were recruited as part of the Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in Parkinson's Disease Study. Prevalence of NMS was determined with the Non-Motor Symptom Questionnaire. HRQoL was recorded with the 39-item Parkinson's Disease Quality of Life Questionnaire (PDQ-39). Further assessments included measures of motor disability, depression, sleep, and cognition. One hundred and fifty-eight patients with newly diagnosed PD and 99 controls participated in this cross-sectional study. Patients reported greater numbers of NMS than controls (mean 8.3 ± 4.3 versus 2.8 ± 2.5 symptoms; P < 0.001). Patients reported lowest HRQoL in the domains assessing bodily discomfort, mobility, and activities of daily living. Motor and nonmotor symptoms impacted negatively upon HRQoL scores. Patients with the postural instability and gait difficulty motor subtype reported worse HRQoL, compared with those with tremor-dominant disease. Depression (P < 0.001), incomplete bowel emptying (P < 0.001), anxiety (P < 0.001), impaired concentration (P < 0.001), memory complaints (P < 0.001), and insomnia (P = 0.001) had the greatest negative impact upon HRQoL. NMS are common in patients with early PD and represent a significant cause of poorer health-related quality of life. Cognitive, neuropsychiatric, and sleep disturbances are particularly associated with reduced well-being. Screening and management of these symptoms should be prioritized at the time of diagnosis. © 2013 International Parkinson and Movement Disorder Society