Yuanchao Zhang and Jiuquan Zhang contributed equally to this work.
Cortical gyrification reductions and subcortical atrophy in Parkinson's disease
Version of Record online: 7 OCT 2013
Copyright © 2013 Movement Disorder Society
Volume 29, Issue 1, pages 122–126, January 2014
How to Cite
Zhang, Y., Zhang, J., Xu, J., Wu, X., Zhang, Y., Feng, H., Wang, J. and Jiang, T. (2014), Cortical gyrification reductions and subcortical atrophy in Parkinson's disease. Mov. Disord., 29: 122–126. doi: 10.1002/mds.25680
Funding agencies: This work was supported by the National Basic Research Program of China (973 program, grant 2011CB707800), the Natural Science Foundation of China (grants 81101000, 81101112, and 91132301), and the Fundamental Research Funds for the Central Universities (grant ZYGX2011J098).
Relevant conflicts of interest/financial disclosures: Yuanchao Zhang: 1ABC,2ABC,3AB; Jiuquan Zhang: 1ABC,2ABC,3AB; Jinping Xu: 1,2BC,3A; Xiu Wu: 1,2BC,3A; Yaling Zhang: 1,2BC,3A; Hua Feng: 1,2BC,3A; Jian Wang: 1,2BC,3A; Tianzi Jiang: 1,2BC,3A.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 23 JAN 2014
- Version of Record online: 7 OCT 2013
- Manuscript Accepted: 19 AUG 2013
- Manuscript Revised: 12 AUG 2013
- Manuscript Received: 12 FEB 2013
- Parkinson's disease;
- local gyrification index;
- cortical gyrification;
- white matter connectivity;
- intracortical organization
Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms. Previous morphometric studies of PD were mainly conducted by measuring gray matter volume and cortical thickness, and little attention has been paid to the morphology of the cortical surface.
Using a surface-based local gyrification index (lGI), this study compared the cortical gyrification patterns of 37 PD patients and 34 matched healthy controls. Volumetric analyses also were performed on the subcortical structures.
Compared with the control group, patients with PD had significantly reduced cortical gyrification in multiple brain regions, which the authors speculated were associated with disruptions in white matter connectivity and suboptimal intracortical organization. In addition, subcortical volume atrophy was identified in the bilateral hippocampus and bilateral caudate of the patients with PD.
Further studies are needed to identify the clinical correlates of the structural abnormalities observed in PD. © 2013 International Parkinson and Movement Disorder Society