Cortical gyrification reductions and subcortical atrophy in Parkinson's disease

Authors

  • Yuanchao Zhang PhD,

    1. Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China
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    • Yuanchao Zhang and Jiuquan Zhang contributed equally to this work.

  • Jiuqun Zhang MD,

    1. Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
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    • Yuanchao Zhang and Jiuquan Zhang contributed equally to this work.

  • Jinping Xu MS,

    1. Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China
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  • Xiu Wu MS,

    1. Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China
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  • Yanling Zhang MD,

    1. Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
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  • Hua Feng MD,

    1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
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  • Jian Wang MD,

    Corresponding author
    1. Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
    • Correspondence to: Dr. Tianzi Jiang, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P. R. China; jiangtz@nlpr.ia.ac.cn; Dr. Jian Wang, Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P. R. China; wangjian_811@yahoo.com

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  • Tianzi Jiang PhD

    Corresponding author
    1. Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China
    2. LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China
    3. The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
    • Correspondence to: Dr. Tianzi Jiang, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P. R. China; jiangtz@nlpr.ia.ac.cn; Dr. Jian Wang, Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P. R. China; wangjian_811@yahoo.com

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  • Funding agencies: This work was supported by the National Basic Research Program of China (973 program, grant 2011CB707800), the Natural Science Foundation of China (grants 81101000, 81101112, and 91132301), and the Fundamental Research Funds for the Central Universities (grant ZYGX2011J098).

  • Relevant conflicts of interest/financial disclosures: Yuanchao Zhang: 1ABC,2ABC,3AB; Jiuquan Zhang: 1ABC,2ABC,3AB; Jinping Xu: 1,2BC,3A; Xiu Wu: 1,2BC,3A; Yaling Zhang: 1,2BC,3A; Hua Feng: 1,2BC,3A; Jian Wang: 1,2BC,3A; Tianzi Jiang: 1,2BC,3A.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms. Previous morphometric studies of PD were mainly conducted by measuring gray matter volume and cortical thickness, and little attention has been paid to the morphology of the cortical surface.

Methods

Using a surface-based local gyrification index (lGI), this study compared the cortical gyrification patterns of 37 PD patients and 34 matched healthy controls. Volumetric analyses also were performed on the subcortical structures.

Results

Compared with the control group, patients with PD had significantly reduced cortical gyrification in multiple brain regions, which the authors speculated were associated with disruptions in white matter connectivity and suboptimal intracortical organization. In addition, subcortical volume atrophy was identified in the bilateral hippocampus and bilateral caudate of the patients with PD.

Conclusions

Further studies are needed to identify the clinical correlates of the structural abnormalities observed in PD. © 2013 International Parkinson and Movement Disorder Society

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