Funding agencies: This study was supported by the National Basic Research Program (973 Program; no. 2011CB510002, 2012CB944601, and 2012CB517902 to Hong Jiang), New Century Excellent Talents in University from the Ministry of Education (no. NCET-10-0836 to Hong Jiang), and the National Natural Science Foundation of China (no. 81271260, 30971585, 30871354, 30710303061, and 30400262 to Hong Jiang).
Increase of the plasma α-synuclein levels in patients with multiple system atrophy
Article first published online: 30 SEP 2013
© 2013 International Parkinson and Movement Disorder Society
Volume 29, Issue 3, pages 375–379, March 2014
How to Cite
Sun, Z.-F., Xiang, X.-S., Chen, Z., Zhang, L., Tang, B.-S., Xia, K. and Jiang, H. (2014), Increase of the plasma α-synuclein levels in patients with multiple system atrophy. Mov. Disord., 29: 375–379. doi: 10.1002/mds.25688
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 17 MAR 2014
- Article first published online: 30 SEP 2013
- Manuscript Accepted: 12 AUG 2013
- Manuscript Revised: 4 AUG 2013
- Manuscript Received: 4 JAN 2013
- multiple system atrophy;
- enzyme-linked immunosorbent assay;
- Unified Multiple System Atrophy Rating Scale
Multiple system atrophy, a sporadic neurodegenerative disease, is characterized by the presence of high numbers of glial cytoplasmic inclusions mainly formed by α-synuclein protein, which is encoded by the SNCA gene. To date, however, few studies have investigated the plasma α-synuclein levels in patients with multiple system atrophy. We studied plasma α-synuclein concentrations by using an enzyme-linked immunosorbent assay in 74 patients with multiple system atrophy and 90 healthy controls. The plasma α-synuclein levels were significantly elevated in patients who had multiple system atrophy compared with the control group (P = 0.000). In a subgroup of 48 patients who had probable multiple system atrophy, there was a weakly negative correlation between plasma α-synuclein levels and subscores on Unified Multiple System Atrophy Rating Scale item VI (rs = −0.307; P = 0.034). Plasma α-synuclein levels were elevated in patients with multiple system atrophy, and these levels may be decreased with the development of disease. © 2013 International Parkinson and Movement Disorder Society.