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Increase of the plasma α-synuclein levels in patients with multiple system atrophy

Authors

  • Zhan-Fang Sun MD,

    1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
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  • Xiao-Shuang Xiang MD,

    1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
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  • Zhao Chen MD,

    1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
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  • Li Zhang MD,

    1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
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  • Bei-Sha Tang MD,

    1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
    2. Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China
    3. State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, People's Republic of China
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  • Kun Xia PhD,

    1. State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, People's Republic of China
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  • Hong Jiang MD

    Corresponding author
    1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
    2. Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China
    3. State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, People's Republic of China
    • Corresponding author: Dr. Hong Jiang, Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China; jianghong73868@126.com

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  • Funding agencies: This study was supported by the National Basic Research Program (973 Program; no. 2011CB510002, 2012CB944601, and 2012CB517902 to Hong Jiang), New Century Excellent Talents in University from the Ministry of Education (no. NCET-10-0836 to Hong Jiang), and the National Natural Science Foundation of China (no. 81271260, 30971585, 30871354, 30710303061, and 30400262 to Hong Jiang).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Multiple system atrophy, a sporadic neurodegenerative disease, is characterized by the presence of high numbers of glial cytoplasmic inclusions mainly formed by α-synuclein protein, which is encoded by the SNCA gene. To date, however, few studies have investigated the plasma α-synuclein levels in patients with multiple system atrophy. We studied plasma α-synuclein concentrations by using an enzyme-linked immunosorbent assay in 74 patients with multiple system atrophy and 90 healthy controls. The plasma α-synuclein levels were significantly elevated in patients who had multiple system atrophy compared with the control group (P = 0.000). In a subgroup of 48 patients who had probable multiple system atrophy, there was a weakly negative correlation between plasma α-synuclein levels and subscores on Unified Multiple System Atrophy Rating Scale item VI (rs = −0.307; P = 0.034). Plasma α-synuclein levels were elevated in patients with multiple system atrophy, and these levels may be decreased with the development of disease. © 2013 International Parkinson and Movement Disorder Society.

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