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Impaired force control in writer's cramp showing a bilateral deficit in sensorimotor integration

Authors

  • Jean-Pierre Bleton PT,

    1. INSERM U894, Université Paris Descartes, Service de Neurologie, Hôpital Sainte-Anne, Paris, France
    2. CNRS UMR 7287, Aix-Marseille Université, Marseille, France
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    • These authors contributed equally to this work.

  • Maxime Teremetz MSc,

    1. CNRS UMR 8194, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
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    • These authors contributed equally to this work.

  • Marie Vidailhet MD,

    1. INSERM UMR S 975/CNRS UMR 7225/Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Paris, France
    2. UPMC Université Pierre et Marie Curie, and AP-HP, Department of Neurology, Hôpital Pitié-Salpêtrière, Paris, France
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  • Serge Mesure PhD,

    1. CNRS UMR 7287, Aix-Marseille Université, Marseille, France
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  • Marc A. Maier PhD,

    1. CNRS UMR 8194, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    2. Université Paris Diderot, Sorbonne Paris Cité, Paris, France
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  • Påvel G. Lindberg PhD

    Corresponding author
    1. CNRS UMR 8194, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    • Correspondence to: Dr. Påvel Lindberg, CESEM—CNRS UMR 8194, Université Paris Descartes, Sorbonne Paris Cité, 45 rue des Saints Pères, 75270 Paris, France; pavel.lindberg@cch.aphp.fr

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  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

Abnormal cortical processing of sensory inputs has been found bilaterally in writer's cramp (WC). This study tested the hypothesis that patients with WC have an impaired ability to adjust grip forces according to visual and somatosensory cues in both hands.

Methods

A unimanual visuomotor force-tracking task and a bimanual sense of effort force-matching task were performed by WC patients and healthy controls.

Results

In visuomotor tracking, WC patients showed increased error, greater variability, and longer release duration than controls. In the force-matching task, patients underestimated, whereas controls overestimated, the force applied in the other hand. Visuomotor tracking and force matching were equally impaired in both the symptomatic and nonsymptomatic hand in WC patients.

Conclusions

This study provides evidence of bilaterally impaired grip-force control in WC, when using visual or sense of effort cues. This suggests a generalized subclinical deficit in sensorimotor integration in WC. © 2013 International Parkinson and Movement Disorder Society

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