Funding agencies: This work was supported, in part, by the Michael J. Fox Foundation for Parkinson Research.
Gray matter atrophy and freezing of gait in Parkinson's disease: Is the evidence black-on-white?
Version of Record online: 21 OCT 2013
Copyright © 2013 Movement Disorder Society
Volume 29, Issue 1, pages 134–139, January 2014
How to Cite
Herman, T., Rosenberg-Katz, K., Jacob, Y., Giladi, N. and Hausdorff, J. M. (2014), Gray matter atrophy and freezing of gait in Parkinson's disease: Is the evidence black-on-white?. Mov. Disord., 29: 134–139. doi: 10.1002/mds.25697
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 23 JAN 2014
- Version of Record online: 21 OCT 2013
- Manuscript Accepted: 10 SEP 2013
- Manuscript Revised: 1 SEP 2013
- Manuscript Received: 31 JUL 2013
- Parkinson's disease;
- volumetric MRI;
- freezing of gait;
- gray matter
The pathophysiology underlying freezing of gait (FOG) in Parkinson's disease (PD) is poorly understood. We tested whether gray matter (GM) atrophy contributes to FOG in PD.
Voxel-based morphometry quantified GM atrophy in 106 patients who were classified as freezers (n = 30) or nonfreezers (n = 76). Well-matched smaller subgroups were also studied. Balance, gait, and cognitive function were assessed, and we evaluated the relationship between GM, FOG severity, and symptoms associated with FOG.
GM was significantly reduced in the inferior parietal lobe and angular gyrus in the matched freezers (n = 22), compared to nonfreezers (n = 22; P < 0.015, cluster-level corrected). In the entire cohort, FOG severity was related to bilateral caudate volumes.
GM atrophy in cortical (i.e., parietal lobe and angular gyrus) and subcortical areas (i.e., caudate) are related to FOG. Disparities among the existing findings suggest that inferences regarding specific brain regions should be made with caution. © 2013 International Parkinson and Movement Disorder Society