Relevant conflicts of interest/financial disclosures: Nothing to report.
Multisource ascertainment of Huntington disease in Canada: Prevalence and population at risk
Article first published online: 21 OCT 2013
Copyright © 2013 Movement Disorder Society
Volume 29, Issue 1, pages 105–114, January 2014
How to Cite
Fisher, E. R. and Hayden, M. R. (2014), Multisource ascertainment of Huntington disease in Canada: Prevalence and population at risk. Mov. Disord., 29: 105–114. doi: 10.1002/mds.25717
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 23 JAN 2014
- Article first published online: 21 OCT 2013
- Manuscript Accepted: 11 SEP 2013
- Manuscript Revised: 23 AUG 2013
- Manuscript Received: 22 FEB 2013
- Huntington disease;
- population at risk;
There is uncertainty surrounding the accuracy of prevalence estimates for Huntington's disease (HD). The aims of this study were to provide a best estimate of the prevalence and population at risk for HD in the province of British Columbia (BC), Canada, in 2012. HD patients with a clinical and/or genetic diagnosis of HD and individuals at risk for HD were ascertained from multiple sources. Clinical and genetic data were obtained from all available medical, social service, and genetic testing records. Six hundred and thirty-one HD patients and 3,763 individuals at 25% or 50% risk for HD were identified. Prevalence of HD was estimated at 13.7 per 100,000 (95% confidence interval [CI]: 12.6–14.8 per 100,000) in the general population, and 17.2 per 100,000 (95% CI: 15.8–18.6 per 100,000) in the Caucasian population. The population at 25% to 50% risk was estimated at 81.6 per 100,000 (95% CI: 79.0–84.2 per 100,000) individuals. These figures suggest there may be up to 4,700 individuals affected with HD and 14,000 at 50% risk for HD in Canada as well as up to 43,000 individuals affected with HD and 123,000 at 50% risk for HD in the United States. This is the first direct assessment of HD epidemiology in Canada in over three decades. These findings suggest that underascertainment may have led to previous underestimates of prevalence, namely, in Caucasian populations, and will aid in the planning of appropriate resource allocation and service delivery for the HD community. © 2013 International Parkinson and Movement Disorder Society.