Relevant conflicts of interest/financial disclosures: Nothing to report.
Brain SPECT in Sydenham's chorea in remission
Article first published online: 21 NOV 2013
© 2013 Movement Disorder Society
Volume 29, Issue 2, pages 256–258, February 2014
How to Cite
Beato, R., Siqueira, C. F., Marroni, B. J., Boanova, L. G., de Lima, C. F., Maia, D. P., Nattan, M. and Cardoso, F. (2014), Brain SPECT in Sydenham's chorea in remission. Mov. Disord., 29: 256–258. doi: 10.1002/mds.25721
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 20 FEB 2014
- Article first published online: 21 NOV 2013
- Manuscript Accepted: 23 SEP 2013
- Manuscript Revised: 11 SEP 2013
- Manuscript Received: 27 MAY 2013
- Sydenham's chorea;
- basal ganglia;
Sydenham's chorea, a major manifestation of rheumatic fever, is characterized by chorea, behavioral changes, and cognitive dysfunction. Perfusion changes in the basal ganglia are the most frequent imaging findings observed in patients with Sydenham's chorea.
Twelve adult women with Sydenham's chorea in remission underwent brain single-photon emission computed tomography (SPECT). Their scans underwent a quantification process to evaluate the perfusion of Brodmann's areas of the frontal lobes and basal ganglia. The results were compared with the findings from a control group that was matched by age.
A pattern of hyperperfusion in the left putamen was observed in the patient group (P = 0.02). No significant difference was observed in relation to other brain regions.
The findings of brain SPECT suggest that perfusion abnormalities of the basal ganglia may persist even after the remission of abnormal movements in patients with Sydenham's chorea. © 2013 International Parkinson and Movement Disorder Society