Funding agencies: Parkinson's UK; Comprehensive Local Research Network; Lockhart Parkinson's Disease Research Fund.
Primary sleep disorder prevalence in patients with newly diagnosed Parkinson's disease
Article first published online: 4 NOV 2013
© 2013 Movement Disorder Society
Volume 29, Issue 2, pages 259–262, February 2014
How to Cite
Prudon, B., Duncan, G. W., Khoo, T. K., Yarnall, A. J., Burn, D. J. and Anderson, K. N. (2014), Primary sleep disorder prevalence in patients with newly diagnosed Parkinson's disease. Mov. Disord., 29: 259–262. doi: 10.1002/mds.25730
Relevant conflicts of interest/financial disclosures: ResMed Ltd. (to B.P.); Newcastle University Lockhart Parkinson's Disease Fund (to G.W.D., T.K.K., A.J.Y.); Michael J. Fox Foundation (to A.J.Y., D.J.B.); NIHR, Wellcome Trust, GlaxoSmithKline Ltd, Parkinson's UK (to D.J.B.); Investigator-Initiated Study grant from Phillips R&D (to K.N.A.).
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 20 FEB 2014
- Article first published online: 4 NOV 2013
- Manuscript Accepted: 1 OCT 2013
- Manuscript Revised: 19 SEP 2013
- Manuscript Received: 4 MAY 2013
- Parkinson's disease;
- REM sleep behavior disorder;
- obstructive sleep apnea;
Sleep disturbance occurs in up to 96% of patients with established Parkinson's disease (PD). We aimed to assess the prevalence of sleep disturbance in newly diagnosed PD.
Newly diagnosed PD patients and controls were recruited. Patients had motor, non-motor, and sleep assessments, including sleep questionnaires, respiratory home monitoring, actigraphy, and sleep diaries. Controls completed cognitive assessments, sleep questionnaires, and diaries.
A total of 106 patients and 99 controls participated. Sleep questionnaire scores were no different between patients and controls. Daytime naps were increased in PD patients on sleep diaries (P > 0.003). Sleepiness was not associated with any motor or non-motor symptom. Periodic limb movements were increased but not associated with restless legs.
Newly diagnosed PD patients had minimal differences in subjective or objective sleep disturbance compared to controls apart from increased daytime naps and symptoms such as dream-enacting behaviors of punching or grabbing. This contrasts with the literature assessing sleep in those with established PD.© 2013 International Parkinson and Movement Disorder Society