Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease

Authors

  • Joshua E. Aman PhD,

    Corresponding author
    1. Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, USA
    2. Center for Clinical Movement Science, University of Minnesota, Minneapolis, Minnesota, USA
    • Correspondence to: Dr. Joshua E. Aman, PhD, University of Minnesota, Human Sensorimotor Control Laboratory School of Kinesiology, Cooke Hall, 1900 University Ave. SE Minneapolis, MN 55455, USA; aman0038@umn.edu

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  • Aviva Abosch MD, PhD,

    1. Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA
    2. Center for Clinical Movement Science, University of Minnesota, Minneapolis, Minnesota, USA
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  • Maggie Bebler APRN,

    1. Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA
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  • Chia-Hao Lu PhD,

    1. Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, USA
    2. Center for Clinical Movement Science, University of Minnesota, Minneapolis, Minnesota, USA
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  • Jürgen Konczak PhD

    1. Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, Minnesota, USA
    2. Center for Clinical Movement Science, University of Minnesota, Minneapolis, Minnesota, USA
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  • Relevant conflicts of interest/financial disclosures: Dr. Aviva Abosch has performed Ad-hoc consulting with Medtronic, Inc. (Minneapolis, MN) and is PI of an investigator-initiated research grant funded by Medtronic. All PD subjects in this study have implanted electrodes developed by Medtronic. All surgeries occurred prior to this study and no funding or devices were provided by Medtronic for this study.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

An established treatment for the motor symptoms of Parkinson's disease (PD) is deep brain stimulation (DBS) of the subthalamic nucleus (STN). Mounting evidence suggests that PD is also associated with somatosensory deficits, yet the effect of STN-DBS on somatosensory processing is largely unknown. This study investigated whether STN-DBS affects somatosensory processing, specifically the processing of tactile and proprioceptive cues, by systematically examining the accuracy of haptic perception of object size. (Haptic perception refers to one's ability to extract object features such as shape and size by active touch.) Without vision, 13 PD patients with implanted STN-DBS and 13 healthy controls haptically explored the heights of 2 successively presented 3-dimensional (3D) blocks using a precision grip. Participants verbally indicated which block was taller and then used their nonprobing hand to motorically match the perceived size of the comparison block. Patients were tested during ON and OFF stimulation, following a 12-hour medication washout period. First, when compared to controls, the PD group's haptic discrimination threshold during OFF stimulation was elevated by 192% and mean hand aperture error was increased by 105%. Second, DBS lowered the haptic discrimination threshold by 26% and aperture error decreased by 20%. Third, during DBS ON, probing with the motorically more affected hand decreased haptic precision compared to probing with the less affected hand. This study offers the first evidence that STN-DBS improves haptic precision, further indicating that somatosensory function is improved by STN-DBS. We conclude that DBS-related improvements are not explained by improvements in motor function alone, but rather by enhanced somatosensory processing. © 2013 International Parkinson and Movement Disorder Society

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