Funding agencies: This study was supported by a Movement Disorder Society of Australia/Novartis Movement Disorder Scholarship.Relevant conflicts of interest/financial disclosures: Nothing to report.Full financial disclosures and author roles may be found in the online version of this article.
Treatment of proximal upper limb tremor with botulinum toxin therapy
Article first published online: 20 NOV 2013
© 2013 International Parkinson and Movement Disorder Society
Volume 29, Issue 6, pages 835–838, May 2014
How to Cite
Kim, S. D., Yiannikas, C., Mahant, N., Vucic, S. and Fung, V. S.C. (2014), Treatment of proximal upper limb tremor with botulinum toxin therapy. Mov. Disord., 29: 835–838. doi: 10.1002/mds.25739
- Issue published online: 6 MAY 2014
- Article first published online: 20 NOV 2013
- Manuscript Accepted: 22 SEP 2013
- Manuscript Revised: 27 AUG 2013
- Manuscript Received: 5 JUN 2013
- proximal tremor;
- wing-beating tremor;
- botulinum toxin
Proximal-dominant upper limb tremor is highly disabling, and there is no effective medical therapy. In this study, we evaluated the efficacy of botulinum toxin (BTX) injections for the treatment of proximal tremor.
We conducted a retrospective analysis of open-label treatment with BTX in 19 patients with proximal tremor. The response to therapy was graded into four categories according to self-reported improvements in tremor and function.
In total, 63% of patients reported moderate or marked benefit, defined as functional improvements sufficient enough to allow feeding or drinking from a cup; whereas 21% of patients reported mild benefit; and 15% of patients reported no benefit. One patient developed severe weakness of shoulder abduction and withdrew from the treatment; otherwise, the therapy was free of side effects.
The current findings support the efficacy of BTX therapy in the treatment of proximal upper limb tremor with minimal side effects. © International Parkinson and Movement Disorder Society © 2013 International Parkinson and Movement Disorder Society