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Effects of deep brain stimulation frequency on bradykinesia of Parkinson's disease

Authors

  • He Huang MS,

    1. Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
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  • Ray L. Watts MD,

    1. Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
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  • Erwin B. Montgomery Jr., MD

    Corresponding author
    1. Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Current affiliation:
    1. Greenville Neuromodulation Center, Greenville, Pennsylvania, USA
    • Correspondence to: Dr. Erwin B. Montgomery, Jr., Greenville Neuromodulation Center, 179 Main St., Greenville, PA 16125, USA; ebmontgomery@wisc.edu

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  • Funding agencies: Dr. Sigmund Rosen Scholarship fund of the University of Alabama at Birmingham (to E.B.M.), the Lanier Family Foundation, and the Charles Ackerman Parkinson Research Fund.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Deep brain stimulation (DBS) in Parkinson's disease (PD) is frequency-dependent. Past studies of the effect of DBS frequency, however, involved scrutiny of too few frequencies to eliminate risk of undersampling. Also, these studies presented averaged measures across subjects; high intersubject variability makes these measures problematic. In this study, 6 subjects with PD were tested in a drug-minimal state. Following 10 minutes of stimulation at the new frequency, all available frequencies were tested. Hand-opening and hand-closing amplitude and frequency were measured in 3 epochs of 15 seconds each. Multiple frequencies (low and high) resulted in peaks of increased movement amplitudes. Peaks were specific and varied among individuals. No clear relationship between stimulation frequency and movement frequency was discovered. In light of the findings, a wider range of stimulation frequencies should be examined, particularly lower frequencies. Most current theories of PD pathophysiology and DBS mechanisms of action fail to explain results of the kind demonstrated herein. © 2013 International Parkinson and Movement Disorder Society

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