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Three-dimensional brain MRI for DBS patients within ultra-low radiofrequency power limits

Authors

  • Subhendra N. Sarkar PhD,

    Corresponding author
    1. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    • Correspondence to: Dr. Subhendra N. Sarkar, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Ansin E/245, Boston, MA 02215; ssarkar@bidmc.harvard.edu

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  • Efstathios Papavassiliou MD,

    1. Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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  • David B. Hackney MD,

    1. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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  • David C. Alsop PhD,

    1. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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  • Ludy C. Shih MD,

    1. Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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  • Ananth J. Madhuranthakam PhD,

    1. Applied Science Laboratory, GE Healthcare, Boston, Massachusetts, USA
    Current affiliation:
    1. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas
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  • Reed F. Busse PhD,

    1. Applied Science Laboratory, GE Healthcare, Madison, Wisconsin, USA
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  • Susan La Ruche BS,

    1. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Current affiliation:
    1. Department of Radiology, South Shore Hospital, Weymouth, Massachusetts
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  • Rafeeque A. Bhadelia MD

    1. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

For patients with deep brain stimulators (DBS), local absorbed radiofrequency (RF) power is unknown and is much higher than what the system estimates. We developed a comprehensive, high-quality brain magnetic resonance imaging (MRI) protocol for DBS patients utilizing three-dimensional (3D) magnetic resonance sequences at very low RF power.

Methods

Six patients with DBS were imaged (10 sessions) using a transmit/receive head coil at 1.5 Tesla with modified 3D sequences within ultra-low specific absorption rate (SAR) limits (0.1 W/kg) using T2, fast fluid-attenuated inversion recovery (FLAIR) and T1-weighted image contrast. Tissue signal and tissue contrast from the low-SAR images were subjectively and objectively compared with routine clinical images of six age-matched controls.

Results

Low-SAR images of DBS patients demonstrated tissue contrast comparable to high-SAR images and were of diagnostic quality except for slightly reduced signal.

Conclusions

Although preliminary, we demonstrated diagnostic quality brain MRI with optimized, volumetric sequences in DBS patients within very conservative RF safety guidelines offering a greater safety margin. © 2014 International Parkinson and Movement Disorder Society

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