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mds25815-sup-0001-suppfig1.tif4643KSUPPORTING FIGURE 1. Image processing and volume determination are shown for the brainstem: (1) Unified segmentation of SPM5 (ie,normalisation, segmentation, and intensity correction) was performed on a T1-weighted volume data set. (2) A binary brainstem mask was derived from the LONI Probabilistic Brain Atlas (LPBA40) by setting all voxels of the maximum-likelihood map belonging to the brainstem to a value of “one,” while all other voxels were set to zero. (3) The modulated white matter image resulting from unified segmentation was multiplied with the brainstem mask. This resulted in a modulated image of the individual brainstem. Due to modulation of the white matter image, the effect of normalization (ie, extension or shrinkage of the investigated structure) was compensated for so that the computed volume represents the volume of the original structure in native space. For volume measurements of gray matter structures, the same image-processing steps were based on the modulated gray matter image.
mds25815-sup-0002-suppinfo.docx327KSupporting Information

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