The first two authors contributed equally to this work.
Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial
Version of Record online: 31 JAN 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 4, pages 479–487, April 2014
How to Cite
Höglinger, G. U., Huppertz, H.-J., Wagenpfeil, S., Andrés, M. V., Belloch, V., León, T., del Ser, T., for the TAUROS MRI Investigators (2014), Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial. Mov. Disord., 29: 479–487. doi: 10.1002/mds.25815
Funding agencies: This study was funded by Noscira SA, Madrid, Spain. Dr. Höglinger is supported by the Deutsche Forschungsgemeinschaft (DFG, HO2402/6-1).
Relevant conflicts of interest/financial disclosures: Three authors were employees of Noscira SA, Madrid, Spain, the company that funded this study.
Full financial disclosures and author roles may be found in the online version of this article.
Members of the TAUROS MRI Investigators are listed in the Appendix.
- Issue online: 3 APR 2014
- Version of Record online: 31 JAN 2014
- Manuscript Accepted: 20 DEC 2013
- Manuscript Revised: 1 OCT 2013
- Manuscript Received: 29 APR 2013
Additional Supporting Information may be found in the online version of this article.
|mds25815-sup-0001-suppfig1.tif||4643K||SUPPORTING FIGURE 1. Image processing and volume determination are shown for the brainstem: (1) Unified segmentation of SPM5 (ie,normalisation, segmentation, and intensity correction) was performed on a T1-weighted volume data set. (2) A binary brainstem mask was derived from the LONI Probabilistic Brain Atlas (LPBA40) by setting all voxels of the maximum-likelihood map belonging to the brainstem to a value of “one,” while all other voxels were set to zero. (3) The modulated white matter image resulting from unified segmentation was multiplied with the brainstem mask. This resulted in a modulated image of the individual brainstem. Due to modulation of the white matter image, the effect of normalization (ie, extension or shrinkage of the investigated structure) was compensated for so that the computed volume represents the volume of the original structure in native space. For volume measurements of gray matter structures, the same image-processing steps were based on the modulated gray matter image.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.