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Patterns of cortical thinning in idiopathic rapid eye movement sleep behavior disorder

Authors

  • Shady Rahayel BSc,

    1. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada
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  • Jacques Montplaisir PhD, MD,

    1. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychiatry, Université de Montréal, Montreal, Quebec, Canada
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  • Oury Monchi PhD,

    1. Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada
    2. Department of Radiology, Radio-Oncology, and Nuclear Medicine, Université de Montréal, Montreal, Quebec, Canada
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  • Christophe Bedetti MSc,

    1. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    2. Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada
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  • Ronald B. Postuma MSc, MD,

    1. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    2. Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada
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  • Simona Brambati PhD,

    1. Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, Université de Montréal, Montreal, Quebec, Canada
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  • Julie Carrier PhD,

    1. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    2. Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada
    3. Department of Psychology, Université de Montréal, Montreal, Quebec, Canada
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  • Sven Joubert PhD,

    1. Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, Université de Montréal, Montreal, Quebec, Canada
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  • Véronique Latreille BSc,

    1. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, Université de Montréal, Montreal, Quebec, Canada
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  • Thomas Jubault PhD,

    1. Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada
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  • Jean-François Gagnon PhD

    Corresponding author
    1. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada
    3. Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada
    • Correspondence to: Dr. Jean-François Gagnon, Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, 5400 Boul. Gouin Ouest, Montréal, Québec, Canada H4J 1C5; gagnon.jean-francois.2@uqam.ca

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  • Funding agencies: This study was supported by grants from the Canadian Institutes of Health Research (J.-F. Gagnon, J. Montplaisir, R.B. Postuma, J. Carrier, and O. Monchi) and the Fonds de Recherche du Québec-Santé (J.-F. Gagnon, J. Montplaisir, and S. Joubert). S. Rahayel and V. Latreille were supported by a scholarship from the Canadian Institutes of Health Research.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Idiopathic rapid eye movement sleep behavior disorder is a parasomnia that is a risk factor for dementia with Lewy bodies and Parkinson's disease. Brain function impairments have been identified in this disorder, mainly in the frontal and posterior cortical regions. However, the anatomical support for these dysfunctions remains poorly understood. We investigated gray matter thickness, gray matter volume, and white matter integrity in patients with idiopathic rapid eye movement sleep behavior disorder. Twenty-four patients with polysomnography-confirmed idiopathic rapid eye movement sleep behavior disorder and 42 healthy individuals underwent a 3-tesla structural and diffusion magnetic resonance imaging examination using corticometry, voxel-based morphometry, and diffusion tensor imaging. In the patients with idiopathic rapid eye movement sleep behavior disorder, decreased cortical thickness was observed in the frontal cortex, the lingual gyrus, and the fusiform gyrus. Gray matter volume was reduced in the superior frontal sulcus only. Patients showed no increased gray matter thickness or volume. Diffusion tensor imaging analyses revealed no significant white matter differences between groups. Using corticometry in patients with idiopathic rapid eye movement sleep behavior disorder, several new cortical regions with gray matter alterations were identified, similar to those reported in dementia with Lewy bodies and Parkinson's disease. These findings provide some anatomical support for previously identified brain function impairments in this disorder. © 2014 International Parkinson and Movement Disorder Society

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