Funding agencies: This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (no. 22590952) to Masahiko Tomiyama.
Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model
Article first published online: 26 FEB 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 3, pages 336–343, March 2014
How to Cite
Nishijima, H., Suzuki, S., Kon, T., Funamizu, Y., Ueno, T., Haga, R., Suzuki, C., Arai, A., Kimura, T., Suzuki, C., Meguro, R., Miki, Y., Yamada, J., Migita, K., Ichinohe, N., Ueno, S., Baba, M. and Tomiyama, M. (2014), Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model. Mov. Disord., 29: 336–343. doi: 10.1002/mds.25826
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 17 MAR 2014
- Article first published online: 26 FEB 2014
- Manuscript Accepted: 30 DEC 2013
- Manuscript Revised: 20 DEC 2013
- Manuscript Received: 3 JUL 2013
- Parkinson's disease;
- synaptic plasticity;
- dendritic spine;
- morphologic change
Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa-induced dyskinesia. Recently, it has been shown that synaptic plasticity is closely linked to morphologic changes of dendritic spines. To evaluate morphologic changes of dendritic spines of two types of striatal medium spiny neurons, which project to the internal segment of globus pallidus or the external segment of globus pallidus, in the levodopa-induced dyskinesia model, we used 6-hydroxydopamine-lesioned rats chronically treated with levodopa. Dendritic spines were decreased and became enlarged in the direct pathway neurons of the model of levodopa-induced dyskinesia. The same levodopa treatment to normal rats, in which no dyskinesia was observed, also induced enlargement of dendritic spines, but not a decrease in density of spines in the direct pathway neurons. These results suggest that a loss and enlargement of dendritic spines in the direct pathway neurons plays important roles in the development of levodopa-induced dyskinesia. © 2014 International Parkinson and Movement Disorder Society