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Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model

Authors

  • Haruo Nishijima MD,

    Corresponding author
    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
    2. Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
    • Correspondence to: Dr. Haruo Nishijima, Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-tsukurimichi, Aomori City, Aomori 030-8553, Japan; hnishijima-tky@umin.ac.jp

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  • Satoko Suzuki MD, PhD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Tomoya Kon MD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Yukihisa Funamizu MD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Tatsuya Ueno MD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
    2. Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Rie Haga MD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Chihiro Suzuki MD, PhD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Akira Arai MD, PhD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Tamaki Kimura MD, PhD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Chieko Suzuki MD, PhD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Reiko Meguro PhD,

    1. Department of Neuroanatomy, Cell Biology, and Histology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Yasuo Miki MD, PhD,

    1. Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Junko Yamada PhD,

    1. Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Keisuke Migita PhD,

    1. Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Noritaka Ichinohe MD, PhD,

    1. Department of Neuroanatomy, Cell Biology, and Histology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Shinya Ueno MD, PhD,

    1. Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Masayuki Baba MD, PhD,

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
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  • Masahiko Tomiyama MD, PhD

    1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan
    2. Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan
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  • Funding agencies: This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (no. 22590952) to Masahiko Tomiyama.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa-induced dyskinesia. Recently, it has been shown that synaptic plasticity is closely linked to morphologic changes of dendritic spines. To evaluate morphologic changes of dendritic spines of two types of striatal medium spiny neurons, which project to the internal segment of globus pallidus or the external segment of globus pallidus, in the levodopa-induced dyskinesia model, we used 6-hydroxydopamine-lesioned rats chronically treated with levodopa. Dendritic spines were decreased and became enlarged in the direct pathway neurons of the model of levodopa-induced dyskinesia. The same levodopa treatment to normal rats, in which no dyskinesia was observed, also induced enlargement of dendritic spines, but not a decrease in density of spines in the direct pathway neurons. These results suggest that a loss and enlargement of dendritic spines in the direct pathway neurons plays important roles in the development of levodopa-induced dyskinesia. © 2014 International Parkinson and Movement Disorder Society

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